New physician-investigators receiving National Institutes of Health research project grants - A historical perspective on the "endangered species"
New physician-investigators receiving National Institutes of Health research project grants - A historical perspective on the "endangered species"
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DOI：
10.1001/jama.297.22.2496
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发表时间：
2007-06-13
影响因子：
120.7
通讯作者：
Korn, David
中科院分区：
文献类型：
--
作者：
Dickler, Howard B.;Di Fang;Korn, David
背景 尽管几十年来人们一直对新医师临床科学家的产生以及他们在接受和维持美国国立卫生研究院 (NIH) 支持的研究方面的成功表示担忧，但没有全面的分析记录首次获得医学博士学位的研究人员的经历。 目的 确定 40 多年来，医师兼科学家竞争 NIH 研究 (R01) 资助的毅力和相对成功程度。 设计、设置和参与者 对所有首次申请者和参与者进行纵向比较研究1964 年至 2004 年间 NIH R01 资助的获得者按主要研究者的主要学位（医学博士、博士或医学博士和博士学位）以及他们拟参与的人体或人体组织研究进行分层。主要结果指标按学术学位和研究类型（临床与非临床）划分的首次和第二次 NIH R01 资助申请人和获得者的数量。结果每年仅作为 NIH 获得医学博士学位的研究者数量R01 补助金申请人在 4 个十年中保持显着稳定（41 年平均值为 707 名[范围，537-983]名申请人）。在首次申请者中，拥有医学博士学位的研究人员在获得资助方面的成功率始终低于拥有博士学位的研究人员（MAP，31%；P=.03 vs 仅医学博士）或同时拥有医学博士学位和博士学位的研究人员（MAP，34%；P）
Context Although concerns have persisted for decades about the production of new physician clinical scientists and their success in receiving and sustaining research supported by the National Institutes of Health (NIH), no comprehensive analysis documents the experiences of first-time investigators with an MD over a long period.Objective To ascertain the perseverance and comparative success of physician-scientists competing for NIH research (R01) grants awarded over 40 years.Design, Setting, and Participants A longitudinal, comparative study of all first-time applicants and recipients of NIH R01 grants between 1964 and 2004 stratified by the principal investigators' major degrees ( MD, PhD, or MD and PhD) and their proposed involvement in research of humans or human tissues.Main Outcome Measures Number of first-and second-time NIH R01 grant applicants and recipients by academic degree and by research type ( clinical vs nonclinical).Results The annual number of first-time investigators with an MD only as NIH R01 grant applicants remained remarkably stable over 4 decades (41-year mean of 707 [ range, 537-983] applicants). Among first-time applicants, those with an MD consistently had less success in obtaining funding ( mean annual percentage [ MAP], 28%) than either investigators with a PhD ( MAP, 31%; P=. 03 vs MD only) or both an MD and a PhD ( MAP, 34%; P