Steep early negative slopes can be demonstrated in pre-movement bereitschaftspotential
Steep early negative slopes can be demonstrated in pre-movement bereitschaftspotential
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DOI：
10.1016/s1388-2457(01)00630-7
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发表时间：
2001-09
影响因子：
4.7
通讯作者：
M. Kukleta;M. Lamarche
中科院分区：
文献类型：
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作者：
M. Kukleta;M. Lamarche
目的该研究提供的数据表明，经典的 Bereitschafts 电位隐藏在其早期成分 (BP1) 中，在重复试验中以不同的时间间隔在运动之前急剧增加的负性。方法在 12 名志愿者中，在自定节奏的手腕弯曲过程中，记录了来自 Fz、Cz、C3、C4 和 Pz 电极的表面脑电图和来自指总屈肌的肌电图。每个受试者收集了 200 个试验。将单个试验分组，以两种不同的方式进行平均。在第一个实验中，对每个受试者进行单次试验来得出个体平均值。在第二步中，根据在创建运动和时间组平均值之前扫描中检测到的相对于基线的小陡峭负移的时间点，将所有单个试验分为几组。小偏移的识别基于计算的沿时间轴移动的 1 s 时间窗口的前半部分和后半部分中的平均幅度的比较。结果在 97.2% 的分析记录中识别出小负偏移。在每个主题中，他们在时间轴上的位置差异很大。个体平均值表现出经典准备电位的特征，即缓慢的早期成分、陡峭的晚期成分、运动皮质的偏侧性。另一方面，所有时间组平均值 (26) 显示出早期的陡峭负移，然后是稳定期，在运动前约 0.5 秒，引起第二次、晚期的陡峭负移。在平均曲线的确定段中计算出的斜率值被用作不同大脑区域的这些变化幅度的测量。多元方差分析显示，在早期斜率（F(4,115)=9.7；P<0.000）和晚期斜率（F(4,115)=22.5；P<0.000）的情况下，电极位置都有显着影响。在这两种情况下，在 Cz 电极下都显示出最大值。与晚期斜率相比，早期斜率的值没有表现出侧向性，这表明前额叶区域在其形成中更为重要。结论我们认为，时间组平均值相对于基线的早期急剧负移的形成是由于心理过程的同步，在经典平均程序下，该心理过程在整个前运动期间均匀分散。
ObjectivesThe study presents data suggesting that the classic bereitschaftspotential hides in its early component (BP1) steep increases of negativity which precede the movement at varying intervals in repeated trials.MethodsIn 12 volunteers, surface EEG from Fz, Cz, C3, C4, and Pz electrodes and EMG from the flexor digitorum communis were recorded during self-paced wrist flexions. Two hundred trials were collected from each subject. The single trials were grouped for averaging in two different ways. In the first one, single trials for each subject were used to create individual averages. In the second, all single trials were divided into groups according to the point in time of small steep negative shift from the baseline detected on sweeps before the movement and time group averages were created. The identification of small shifts was based on the comparison of calculated mean amplitudes in the first and the second half of the 1 s time window moved along the time axis.ResultsThe small negative shifts were identified in 97.2% of analyzed records. In each subject, their position on the time axis varied considerably. Individual averages exhibited the characteristics of classical readiness potential, i.e. slow early component, steep late component, laterality over motor cortices. On the other hand, all time group averages (26) displayed an early steep negative shift followed by plateau which, about 0.5 s before the movement, gave rise to the second, late steep negative shift. The slope values calculated in the definite segments of averaged curves were used as a measure of the amplitude of these shifts over various brain areas. MANOVA showed a significant effect of the electrode position both in the case of early slopes (F(4,115)=9.7; P<0.000) and in the case of late slopes (F(4,115)=22.5; P<0.000). In both cases, the largest value was demonstrated under Cz electrode. In contrast to the late slopes, the values of early slopes did not exhibit laterality and suggested greater importance of pre-frontal regions in their formation.ConclusionWe have suggested that the formation of steep early negative shifts from the baseline in time group averages was due to synchronization of a mental process which, under classical averaging procedure, was dispersed uniformly throughout the pre-movement period.