Deficits in inhibition and flexibility are associated with the APOE-E4 allele in nondemented older adults.
Deficits in inhibition and flexibility are associated with the APOE-E4 allele in nondemented older adults.
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非痴呆老年人的抑制和灵活性缺陷与 APOE-E4 等位基因有关。
DOI：
10.1080/13803390490919001
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发表时间：
2005
影响因子：
2.2
通讯作者：
Bondi,MarkW
中科院分区：
文献类型：
--
作者：
Wetter,SpencerR;Delis,DeanC;Houston,WesS;Jacobson,MarkW;Lansing,Amy;Cobell,Krystal;Salmon,DavidP;Bondi,MarkW
这项前瞻性研究对有AD和其他类型痴呆遗传风险的非痴呆老年人（即APOE e4等位基因）使用了一种新的Stroop测试，该测试包括双重执行功能条件，需要反应抑制和认知转换。结果表明，相对于非e4组，e4组出现了更多的错误，但仅在新的抑制/转换条件下。此外，与非e4组相比，e4组在这项任务上的错误率差异更具异质性，e4组的错误率与整体认知状态（即DRS分数）显著相关，而非e4组则没有。这些研究结果表明，阿尔茨海默病高危人群在反应抑制和认知灵活性方面存在错误易感性，可能预示着阿尔茨海默病临床前执行功能障碍的早期出现。这些微妙的执行功能缺陷与高危个体的整体认知功能之间的联系进一步证明了它们作为AD临床前标记物的实用性。
This prospective study of nondemented older adults at genetic risk for AD and other types of dementia (i.e., APOE e4 allele) utilized a new Stroop test that includes a dual executive-function condition requiring both response inhibition and cognitive switching. Results indicated that, relative to non-e4 subjects, the e4 group committed more errors, but only on the new Inhibition/Switching condition. In addition, error-rate variance on this task was more heterogeneous for the e4 compared to the non-e4 group, and errors rates correlated significantly with global cognitive status (i.e., DRS scores) for the e4 group but not for the non-e4 group. These findings suggest that vulnerability to errors in response inhibition and cognitive flexibility is present in persons at risk for AD and may signal early emergence of executive dysfunction in preclinical AD. The association between these subtle executive-function deficits and the overall cognitive functioning of at-risk individuals provides further evidence of their utility as a possible preclinical marker of AD.