The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the horse
The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the horse
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DOI：
10.1016/j.joca.2010.05.031
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发表时间：
2010-10-01
影响因子：
7
通讯作者：
Cruz, A.
中科院分区：
文献类型：
--
作者：
McIlwraith, C. W.;Frisbie, D. D.;Cruz, A.
目的研究马骨关节炎（OA）的发病机制和治疗方法。本文综述了马掌指关节OA的宏观和微观评价标准，以及马腕中关节OA的骨软骨碎裂-运动模型。方法：对所有已发表的马OA研究进行了回顾，总结了最常见的宏观和微观评分系统，并根据已发表的研究提出了关于马OA评估方法的建议。马OA的定量组织学评估提示其已经广泛使用，并与其他评分系统相似。提供了滑膜炎和OA肉眼病变的组织学评分以及自然发生OA的钙化软骨和软骨下骨的变化。结论所提出的用于评估马关节组织的系统提供了量化OA变化的有用方法。相信最近描述的在整形和肉眼测量中增加定量示踪将改善关节炎的整体评估。软骨改变。(C)2010国际骨关节炎研究学会出版由爱思唯尔有限公司版权所有
Objective Equine models of osteoarthritis (OA) have been used to investigate pathogenic pathways of OA and evaluate therapeutic candidates for naturally occurring equine OA which is a significant clinical disease in the horse This review focuses on the macroscopic and microscopic criteria for assessing naturally occurring OA in the equine metacarpophalangeal Joint as well as the osteochondral fragment-exercise model of OA in the equine middle carpal jointMethods: A review was conducted of all published OA studies using horses and the most common macroscopic and microscopic scoring systems were summarized Recommendations regarding methods of OA assessment in the horse have been made based on published studiesResults A modified Mankin scoring system is recommended for semi-quantitative histological assessment of OA in horses clue to its already widespread use and similarity to other scoring systems Recommendations are also provided for histological scoring of synovitis and macroscopic lesions of OA as well as changes in the calcified cartilage and subchondral bone of naturally occuring OAConclusions The proposed system for assessment of equine articular tissues provides a useful method to quantify OA change It is believed that addition of quantitative tracing onto plastic and macroscopic measurement as recently described would be an improvement for overall assessment of articular cartilage change. (C) 2010 Osteoarthritis Research Society International Published by Elsevier Ltd All rights reserved