Fascin and cortactin expression is correlated with a poor prognosis in hepatocellular carcinoma
Fascin and cortactin expression is correlated with a poor prognosis in hepatocellular carcinoma
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肌成束蛋白和皮质蛋白表达与肝细胞癌的不良预后相关
DOI：
10.1097/meg.0b013e3283515a18
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发表时间：
2012-06-01
影响因子：
2.1
通讯作者：
Ji, Guozhong
中科院分区：
文献类型：
--
作者：
Huang, Xiaodan;Ji, Jie;Ji, Guozhong
目的探讨Fasin和Cortactin蛋白在肝细胞癌中的表达及其与临床病理参数和生存期的关系。方法收集77例肝细胞癌标本和7例正常肝组织标本。免疫组织化学方法检测Fas、Cortactin的表达。对接受肝细胞癌治疗的患者也进行了随访。在这74名患者中，使用Kaplan-Meier评估生存结果。结果在肝细胞癌组织中，Fascin和Cortactin表达上调。Fasin的阳性表达与组织分化程度和转移密切相关。Cortactin的阳性表达与组织分化、转移和国际抗癌联盟的T分期显著相关。Fasin阳性和Cortactin阳性患者的生存期明显缩短，中位生存期较短。结论Fasin和Cortactin可能是反映肝癌恶性程度和转移的重要指标，对预测肝癌的预后有一定价值。
Objectives The aim of this study was to investigate the relationship between fascin and cortactin protein expression and clinicopathological parameters and survival time in patients with hepatocellular carcinoma (HCC). Methods A total of 77 specimens of HCC and seven specimens of normal liver tissues were collected. The expressions of fascin and cortactin were examined by immunohistochemical staining. The patients from whom the HCCs were taken were also followed up. In these 74 patients, Kaplan–Meier was used to assess survival outcomes. Results The data revealed that fascin and cortactin expressions were upregulated in the HCC samples. The positive expression of fascin significantly correlated with histological differentiation and metastasis. The positive expression of cortactin significantly correlated with histological differentiation, metastasis, and T stage (International Union Against Cancer). Survival time of the patients with positive fascin expression and positive cortactin expression was significantly decreased, and the median survival duration was short. Conclusion Fascin and cortactin might be important indicators of the malignancy and metastasis of liver cancer, and may have predictive value in the prognosis of HCC.