The biogenesis of lysosomes: Is it a kiss and run, continuous fusion and fission process?
The biogenesis of lysosomes: Is it a kiss and run, continuous fusion and fission process?
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DOI：
10.1002/bies.950181108
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发表时间：
1996-01-01
期刊：
影响因子：
4
通讯作者：
Desjardins, Michel
中科院分区：
文献类型：
--
作者：
Storrie, Brian;Desjardins, Michel
分子通过一系列复杂的途径转移到溶酶体，即真核细胞中主要的酸性消化区，这些途径在内核体晚期/溶酶体前区汇合。在这里，我们讨论这个隔室和溶酶体之间的关系。我们认为溶酶体在细胞内通过一系列重复的吻和跑、短暂的融合和裂变过程与内核体晚期/前溶酶体隔室维持。这些过程的方向性可能由pH梯度和恢复机制赋予。未来测试这一假说和任何其他关于溶酶体生物发生的假说的挑战将是建立分子机制。
Molecules are transferred to lysosomes, the major, acid pH, digestive compartment in eukaryotic cells, by a complex series of pathways that converge at a late endosome/prelysosomal compartment. Here, we discuss the relationship between this compartment and the lysosome. We propose that lysosomes are maintained within cells by a repeated series of kiss and run, transient fusion and fission processes with the late endosome/prelysosome compartment. Directionality to these processes may be conferred by pH gradients and retrieval mechanisms. The future challenge in testing this and any other proposed hypothesis for lysosomal biogenesis will be the establishment of molecular mechanisms.