Regulation of blood flow by prostaglandins.
Regulation of blood flow by prostaglandins.
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前列腺素调节血流。
DOI：
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发表时间：
2004
影响因子：
4.5
通讯作者：
M. Kjaer
中科院分区：
文献类型：
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作者：
R. Boushel;H. Langberg;N. Risum;M. Kjaer
前列腺素 (PG) 与血栓素一起属于前列腺素家族，主要由环氧合酶从花生四烯酸产生。已知 PG 可以刺激血小板聚集，介导炎症和水肿，在骨代谢和结缔组织（例如结缔组织）的生物适应中发挥作用。肌腱。本综述涵盖了 PG 在静息时以及运动和反应性充血等代谢需求增加期间调节组织血流的作用。有强有力的证据表明，PG 有助于提高多种组织在休息时和反应性充血期间的血流量。它们在运动过程中调节肌肉血流量大幅增加的作用尚不清楚，这可能是通过冗余机制来解释的。已知特定血管舒张物质之间存在多种相互作用，因此 PG 可以与其他物质协同作用并导致功能性充血。此外，有证据表明 PG 具有差异性、组织特异性影响，它们对运动过程中的血流的影响可能是深远的。
Prostaglandins (PGs) belong to the family of prostanoids together with thromboxanes and are produced mainly from arachadonic acid by the enzyme cyclooxygenase. PGs are known to stimulate platelet aggregation, mediate inflammation and edema, play a role in bone metabolism and in biological adaptation of connective tissues e.g. tendon. This review covers the role of PG for mediating tissue blood flow at rest and during increases in metabolic demand such as exercise and reactive hyperaemia. There is strong evidence that PGs contribute to elevate blood flow at rest and during reactive hyperaemia in a variety of tissues. Their role for regulating the large increases in muscle blood flow during exercise is less clear which may be explained by redundant mechanisms. Several interactions are known to exist between specific vasodilator substances, and therefore PGs can act in synergy with other substances and contribute to functional hyperaemia. Furthermore, there is evidence for differential, tissue-specific influences of PGs where their influence on blood flow during exercise may be profound.