Animals as sentinels of chemical terrorism agents: an evidence-based review.
Animals as sentinels of chemical terrorism agents: an evidence-based review.
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动物作为化学恐怖主义制剂的哨兵：基于证据的审查。
DOI：
10.1080/15563650701664905
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
Dein,FJoshua
中科院分区：
文献类型：
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作者：
Rabinowitz,Peter;Wiley,James;Odofin,Lynda;Wilcox,Matthew;Dein,FJoshua
目的：本系统评价的目的是确定动物可以作为化学恐怖主义剂攻击的哨兵的证据。方法：系统地检索生物医学文献，寻找暴露于某些恐怖主义化学武器的野生或家养动物与人类相比具有更大易感性、更短潜伏期或更高暴露风险的证据。此外，我们还检索了有关这些动物作为化学战剂哨兵的文献报道。结果：对于少数化学战剂，只有有限的证据表明家养和/或野生动物可以在化学战剂空中攻击后向人类提供哨兵信息，这通常与环境暴露的可能性增加有关。其中一些证据是基于轶事的案例报告，在许多情况下，高质量的化学恐怖主义剂的证据比较敏感性，暴露，和潜伏期之间的人类和哨兵动物specieswerenfound.Conclusion。目前，有常规使用的动物作为空中化学战剂的哨兵的证据不足。与此同时，毒物中心的监测系统应该包括动物的叫声，兽医和医生之间更多的沟通可以帮助为化学恐怖袭击做好准备。需要进一步分析哨兵动物物种和人类之间的化学战剂毒性比较。
Objectives.The goal of this systematic review was to identify evidence that animals could serve as sentinels of an attack with a chemical terrorism agent.Methods.The biomedical literature was systematically searched for evidence that wild or domestic animals exposed to certain chemical weapons of terrorism had either greater susceptibility, shorter latency period, or increased exposure risk versus humans. Additionally, we searched for documented reports of such animals historically serving as sentinels for chemical warfare agents.Results.For a small number of agents, there was limited evidence that domestic and/or wild animals could provide sentinel information to humans following an airborne attack with chemical agents, usually related to increased potential for environmental exposure. Some of this evidence was based on anecdotal case reports, and in many cases high quality chemical terrorism agent evidence regarding comparative susceptibility, exposure, and latency between humans and sentinel animal species was not found.Conclusion.Currently, there is insufficient evidence for routine use of animals as sentinels for airborne chemical warfare agents. At the same time, Poison Center surveillance systems should include animal calls, and greater communication between veterinarians and physicians could help with preparedness for a chemical terrorism attack. Further analysis of comparative chemical warfare agent toxicity between sentinel animal species and humans is needed.