Ferulic acid prevents lead-induced testicular oxidative stress and suppressed spermatogenesis in rats
Ferulic acid prevents lead-induced testicular oxidative stress and suppressed spermatogenesis in rats
复制标题
DOI：
10.1111/and.12798
复制
发表时间：
2018-02-01
期刊：
影响因子：
2.4
通讯作者：
Roghani, M.
中科院分区：
文献类型：
--
作者：
Hasanein, P.;Fazeli, F.;Roghani, M.
铅会影响包括睾丸在内的多个器官系统。我们研究了阿魏酸 (FA) 对铅诱导的大鼠氧化应激和精子发生抑制的影响。动物接受醋酸铅（饮用水中 500 毫克/升）和/或 FA（50 毫克/公斤，例如）八周。铅会增加睾丸丙二醛（MDA）和亚硝酸盐的水平，并降低谷胱甘肽（GSH）的含量和过氧化氢酶（CAT）的活性。铅会降低睾丸重量和睾酮水平。领先组的精子参数下降。 FA 改善了铅组睾丸重量、血清睾酮以及精子数量、活力、活力和正常形态的下降。 FA 提高了抗氧化能力以及精子数量、活力、活力和正常形态。 FA 通过恢复退化、萎缩和肾小管紊乱，降低了 Johnsen 的平均睾丸活检评分 (MTBS) 标准。 FA 还使铅组中的精原细胞、精母细胞和精细胞数量正常化，并导致间质细胞和支持细胞数量增加。 FA 通过抑制脂质过氧化和增强抗氧化防御系统，对铅引起的睾丸氧化应激和精子疾病显示出有益的作用。 FA 对 Leydig 细胞的积极作用可能与恢复铅组中的睾酮水平有关。 FA 被认为是保护睾丸免受铅中毒有害影响的潜在候选者。
Lead affects multiple organ systems including testis. We investigated the effects of ferulic acid (FA) on lead-induced oxidative stress and spermatogenesis suppression in rats. Animals received lead acetate (500mg/L in drinking water) and/or FA (50mg/kg, i.g.) for eight weeks. Lead increased testicular malondialdehyde (MDA) and nitrite levels and decreased glutathione (GSH) content and catalase (CAT) activity. Lead decreased testis weight and testosterone level. Sperm parameters decreased in lead group. FA ameliorated the decreased testis weight, serum testosterone as well as sperm count, viability, motility and normal morphology in lead group. FA improved antioxidant capacity as well as sperm count, viability, motility and normal morphology. FA decreased Johnsen's mean testicular biopsy score (MTBS) criteria by restoring degeneration, atrophy and tubular disarrangement. FA also normalised spermatogonia, spermatocytes and spermatids numbers in lead group and led to increases in number of Leydig and Sertoli cells. FA showed beneficial effects in lead-induced testicular oxidative stress and spermatological disorders, through inhibiting lipid peroxidation and enhancing antioxidant defence systems. The positive effects of FA on Leydig cells may be involved in restoring testosterone levels in lead group. FA can be considered a potential candidate to protect testis against the deleterious effect of lead intoxication.