Gene-dependent effect of lithium on circadian rhythms in mice (Mus musculus).
Gene-dependent effect of lithium on circadian rhythms in mice (Mus musculus).
复制标题
锂对小鼠昼夜节律的基因依赖性影响（小家鼠）。
DOI：
10.3109/07420528609083155
复制
发表时间：
1986
影响因子：
2.8
通讯作者：
R. H. Exner
中科院分区：
文献类型：
--
作者：
B. Possidente;R. H. Exner
锂已被证明可以延长各种物种的自由运行的昼夜节律周期。在这里，我们表明，碳酸锂差异延长自由运行期间的昼夜节律轮运行节奏的BALB/CByJ和C57 BL/10 Sn近交系小鼠品系。这一结果支持了先前的证据，即锂延长哺乳动物的昼夜节律，也表明基因差异可以介导个体差异对锂治疗的反应。
Lithium has been shown to lengthen free-running circadian periods in a variety of species. Here we show that lithium carbonate differentially lengthens the free-running period of a circadian wheel running rhythm in BALB/CByJ and C57BL/10Sn inbred mouse strains. This result supports previous evidence that lithium lengthens mammalian circadian rhythms, and also demonstrates that gene differences can mediate individual differences in response to lithium treatment.