Serotonergic modulation of resting state default mode network connectivity in healthy women
Serotonergic modulation of resting state default mode network connectivity in healthy women
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DOI：
10.1007/s00726-015-2137-4
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发表时间：
2016-04-01
期刊：
影响因子：
3.5
通讯作者：
Zepf, F. D.
中科院分区：
文献类型：
--
作者：
Helmbold, K.;Zvyagintsev, M.;Zepf, F. D.
默认模式网络（DMN）在内在思维过程中起着核心作用。DMN连接的改变与大脑5-羟色胺合成减少有关。大脑5-羟色胺合成减少还与缺乏冲动控制和各种精神疾病有关。在这里，我们研究了内源性功能连接（FC）内的DMN在健康的成年女性，控制月经周期阶段的多巴胺能调制。18名处于卵泡期的健康女性（年龄20-31岁）参加了一项5-羟色胺耗竭的双盲对照交叉研究。急性色氨酸耗竭（ATD）和平衡氨基酸负荷（BAL）（用作对照条件）在两个单独的评估日应用。神经静息状态的数据，使用功能磁共振成像（fMRI）和个人特质冲动得分。与BAL相比，ATD显著降低了楔前叶中DMN的FC（与自我参照思维相关），并增强了额叶皮层中DMN的FC（与认知推理相关）。中央前回中BAL和ATD之间与DMN的连接性差异与5-羟色胺耗竭的幅度显著相关。右额内侧回和左额上级回与DMN的连接差异与特质冲动性呈负相关。这些发现部分偏离了先前在男性中获得的发现，并强调了性别特异性研究和控制月经周期的重要性，以进一步阐明ATD诱导的内在思维过程变化的机制。
The default mode network (DMN) plays a central role in intrinsic thought processes. Altered DMN connectivity has been linked to diminished cerebral serotonin synthesis. Diminished brain serotonin synthesis is further associated with a lack of impulse control and various psychiatric disorders. Here, we investigated the serotonergic modulation of intrinsic functional connectivity (FC) within the DMN in healthy adult females, controlling for the menstrual cycle phase. Eighteen healthy women in the follicular phase (aged 20-31 years) participated in a double-blind controlled cross-over study of serotonin depletion. Acute tryptophan depletion (ATD) and a balanced amino acid load (BAL), used as the control condition, were applied on two separate days of assessment. Neural resting state data using functional magnetic resonance imaging (fMRI) and individual trait impulsivity scores were obtained. ATD compared with BAL significantly reduced FC with the DMN in the precuneus (associated with self-referential thinking) and enhanced FC with the DMN in the frontal cortex (associated with cognitive reasoning). Connectivity differences with the DMN between BAL and ATD in the precentral gyrus were significantly correlated with the magnitude of serotonin depletion. Right medial frontal gyrus and left superior frontal gyrus connectivity differences with the DMN were inversely correlated with trait impulsivity. These findings partially deviate from previous findings obtained in males and underline the importance of gender-specific studies and controlling for menstrual cycle to further elucidate the mechanism of ATD-induced changes within intrinsic thought processes.