Caveolin-1 and Caveolin-2 Can Be Antagonistic Partners in Inflammation and Beyond.
Caveolin-1 and Caveolin-2 Can Be Antagonistic Partners in Inflammation and Beyond.
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DOI：
10.3389/fimmu.2017.01530
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发表时间：
2017
影响因子：
7.3
通讯作者：
de Almeida CJG
中科院分区：
文献类型：
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作者：
de Almeida CJG
Caveolins是CAV基因家族编码的Caveolae的主要蛋白组分。在大多数组织中，caveolin-1（Cav-1）和caveolin-2（Cav-2）共表达，并且Cav-2靶向caveolae依赖于与Cav-1形成异源寡聚体。尽管如此，Cav-2具有不可预测的活性，在一些细胞过程的调节中与Cav-1相反。虽然Cav-1作为炎症过程和免疫反应中细胞信号传导的调节剂的主要作用已在其他地方进行了广泛的讨论，本次审查的目的是集中在数据揭示Cav-1和Cav-2的不同活性，这表明这些蛋白质拮抗性地微调各种炎症相关的细胞过程。
Caveolins, encoded by the CAV gene family, are the main protein components of caveolae. In most tissues, caveolin-1 (Cav-1) and caveolin-2 (Cav-2) are co-expressed, and Cav-2 targeting to caveolae depends on the formation of heterooligomers with Cav-1. Notwithstanding, Cav-2 has unpredictable activities, opposing Cav-1 in the regulation of some cellular processes. While the major roles of Cav-1 as a modulator of cell signaling in inflammatory processes and in immune responses have been extensively discussed elsewhere, the aim of this review is to focus on data revealing the distinct activity of Cav-1 and Cav-2, which suggest that these proteins act antagonistically to fine-tune a variety of cellular processes relevant to inflammation.