Genetic analysis of a mammalian wound-healing trait
Genetic analysis of a mammalian wound-healing trait
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DOI：
10.1073/pnas.95.20.11792
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发表时间：
1998-09-29
影响因子：
11.1
通讯作者：
Heber-Katze, E
中科院分区：
文献类型：
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作者：
McBrearty, BA;Clark, LD;Heber-Katze, E
哺乳动物组织的伤口愈合是维持机体完整性的重要过程。通常在成年哺乳动物中研究的伤口愈合的一般机制是修复，而不是在更原始的脊椎动物中看到的再生。我们最近发现，MRL/MpJ小鼠，与所有其他小鼠品系不同，经历快速和完全的伤口愈合，类似于再生。具体来说，穿透式手术耳孔伤口愈合后不会留下疤痕
Wound healing of mammalian tissue is an essential process in the maintenance of body integrity. The general mechanism of wound healing usually studied in adult mammals is repair, in contrast to the regeneration seen in more primitive vertebrates. We recently have discovered that MRL/MpJ mice, unlike all other strains of mice tested, undergo rapid and complete wound closure that resembles regeneration. Specifically, through-and-through surgical ear hole wounds close without scarring in