D-allose, an all-cis aldo-hexose, suppresses development of salt-induced hypertension in Dahl rats
D-allose, an all-cis aldo-hexose, suppresses development of salt-induced hypertension in Dahl rats
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DOI：
10.1097/01.hjh.0000182523.29193.e3
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发表时间：
2005-10-01
影响因子：
4.9
通讯作者：
Abe, Y
中科院分区：
文献类型：
--
作者：
Kimura, S;Zhang, GX;Abe, Y
目的D-阿洛糖是一种全顺式醛己糖，无热量，具有抗氧化作用。我们在两种遗传性高血压动物模型中研究了口服D-阿洛糖补充对高血压发展和氧化状态的影响：Dahl盐敏感性高血压（DS）大鼠和自发性高血压大鼠。方法和结果喂食4%盐饮食4周的DS大鼠的收缩压从122 +/- 8显著增加到161 +/-8。5 mmHg，与正常盐饮食喂养的DS大鼠相比（4周时为1138 ± 5 mmHg），而每日以2 g/kg剂量向盐负荷DS大鼠一致补充D-阿洛糖而非D-葡萄糖可抑制高血压的发生（135 - 7毫米汞柱，4周），伴随着减少超氧化物的产生，在主动脉中的光泽精化学发光和二氢乙锭染色确定。补充D-阿洛糖可抑制盐负荷性糖尿病大鼠尿蛋白分泌的增加（喂食0.5%盐的DS大鼠，18.2 +/- 6.3 mg/天;单独喂食4%盐的DS大鼠，81.8 +/- 16.5 mg/天;喂食4%盐+D-阿洛糖的DS大鼠，31.3 +/- 11.8 mg/天; DS大鼠喂食4%盐+D-葡萄糖，85.3 +/- 20.5 mg/天）。另一方面，补充D-阿洛糖对自发性高血压大鼠血压和高血压早期主动脉超氧化物产生无明显影响。结论这些结果强调了氧化应激增强在DS大鼠高血压发病机制中的作用，并提示补充D-阿洛糖预防盐敏感性高血压的可能性。J Hypertens 23：1887-1894（c）2005 Lippincott威廉姆斯&威尔金斯。
Objective D-allose, an all-cis aldo-hexose, is non-caloric and possesses antioxidant properties. We investigated the effects of oral D-allose supplementation on the development of high blood pressure and the oxidative status in two genetically hypertensive animal models: Dahl salt-sensitive hypertensive (DS) rats and spontaneously hypertensive rats.Methods and results The systolic blood pressure of DS rats fed a 4% salt diet for 4 weeks significantly increased from 122 +/- 8 to 161 +/- 5 mmHg as compared with DS rats fed a normal salt diet (1138 5 mmHg at 4 weeks), whereas concordant supplementation Of D-allose, but not D-glucose, with a dose of 2 g/kg daily to salt-loaded DS rats suppressed the development of high blood pressure (135 7 mmHg at 4 weeks), accompanied with decreases in superoxide production in the aorta that was determined by the lucigenin chemiluminescence and dihydroethidium staining. The increases of urinary protein secretion of salt-loaded DS rats were prevented by D-allose supplementation (DS rats fed 0.5% salt, 18.2 +/- 6.3 mg/day; DS rats fed 4% salt alone, 81.8 +/- 16.5 mg/day; DS rats fed 4% salt + D-allose, 31.3 +/- 11.8 mg/day; DS rats fed 4% salt + D-glucose, 85.3 +/- 20.5 mg/day). On the other hand, D-allose supplementation in spontaneously hypertensive rats had no significant effect on the blood pressure or the aortic superoxide production during the early developing stage of hypertension.Conclusions These results underscore the role of enhanced oxidative stress in the pathogenesis of high blood pressure development in DS rats, and suggest the possibility Of D-allose supplementation for prevention of salt-sensitive hypertension. J Hypertens 23:1887-1894 (c) 2005 Lippincott Williams & Wilkins.