The relationship between brain glucose metabolism and insulin resistance in subjects with normal cognition - a study based on 18F-FDG PET
The relationship between brain glucose metabolism and insulin resistance in subjects with normal cognition - a study based on 18F-FDG PET
复制标题
DOI：
10.1097/mnm.0000000000001511
复制
发表时间：
2022-03-01
影响因子：
1.5
通讯作者：
Shao, Xiaoliang
中科院分区：
文献类型：
--
作者：
Chen, Yuqi;Qiu, Chun;Shao, Xiaoliang
目的胰岛素抵抗可增加认知功能障碍和痴呆的危险性。我们的目的是使用F-18-FDG PET显像来探讨胰岛素抵抗对认知正常人脑葡萄糖代谢的影响。方法189名认知功能正常的受试者接受PET检查。胰岛素抵抗的稳态模型评估（HOMA-IR）用于评估胰岛素抵抗的存在。采用多元线性回归和广义相加模型分析HOMA-IR与全脑葡萄糖代谢的相关性，并评估各种协变量的影响。应用SPM 12软件评价胰岛素抵抗对脑葡萄糖代谢的局部影响。结果在充分校正混杂因素后，HOMA-IR与脑葡萄糖代谢呈近似线性负相关（β =-0.219，T =-3.331，P = 0.021）。与正常人相比，胰岛素抵抗者双侧颞中回、双侧额中回、右侧中央前回、右侧额下回、右侧楔状叶和双侧小脑区葡萄糖代谢降低。在认知正常的受试者中，全身性胰岛素抵抗对脑葡萄糖代谢有显著影响。结论F-18-FDG脑PET显像有助于早期诊断和治疗胰岛素抵抗引起的脑葡萄糖代谢改变。
Objective Insulin resistance can increase the risk of cognitive dysfunction and dementia. Our purpose is to use F-18-FDG PET imaging to explore the effect of insulin resistance on brain glucose metabolism in cognitively normal subjects. Methods A total of 189 cognitively normal subjects who underwent PET examinations were enrolled. The homeostasis model assessment of insulin resistance (HOMA-IR) was used to evaluate the presence of insulin resistance. Multivariate linear regression and generalized additive models were used to analyze the association between HOMA-IR and glucose metabolism in the whole brain and evaluate the effects of various covariates. The SPM12 software was used to evaluate the regional effect of insulin resistance on brain glucose metabolism. Results After being fully adjusted for confounding factors, HOMA-IR showed an approximately linear negative correlation with brain glucose metabolism (beta = -0.219, T = -3.331, P = 0.021). Compared with normal subjects, insulin-resistant subjects had reduced glucose metabolism in bilateral middle temporal gyrus, bilateral middle frontal gyrus, right precentral gyrus, right inferior frontal gyrus, right cuneiform lobe and bilateral cerebellar regions. In cognitively normal subjects, systemic insulin resistance has a significant effect on brain glucose metabolism. Conclusions F-18-FDG brain PET imaging could be helpful for the early diagnosis and treatment of changes in brain glucose metabolism caused by insulin resistance.