Ozonation of trimethoprim in aqueous solution: Identification of reaction products and their toxicity
Ozonation of trimethoprim in aqueous solution: Identification of reaction products and their toxicity
复制标题
DOI：
10.1016/j.watres.2013.02.048
复制
发表时间：
2013-05-15
期刊：
影响因子：
12.8
通讯作者：
Yu, Gang
中科院分区：
文献类型：
--
作者：
Kuang, Jiangmeng;Huang, Jun;Yu, Gang
本工作旨在更好地了解典型抗生素药物甲氧苄啶在水溶液中的分带过程。当臭氧投加量达到3.5mg/L时，母体化合物几乎完全降解，没有矿化。使用电喷雾四极杆飞行时间质谱仪鉴定了21种降解产物。提出了几种臭氧化途径，包括羟基化、脱甲基化、羰基化、脱氨基化和亚甲基断裂。选用发光细菌发光杆菌和青海弧菌对臭氧氧化产物进行了毒性评价。对于P. phosphoreum，与母体化合物相比，观察到更高水平的毒性，但对于V. qinghaiensis观察到的毒性变化可忽略不计，表明对于相同的水样的不同作用模式。定量构效关系分析进一步证实了这一点。这一工作证明了臭氧而不是羟基自由基在反应中的主导作用和分区后的潜在风险。(C)2013爱思唯尔有限公司保留所有权利。
This work aimed to better understand the zonation process of a typical antibiotic pharmaceutical, trimethoprim in aqueous solution. The parent compound was almost completely degraded with ozone dose up to 3.5 mg/L with no mineralization. Twenty one degradation products were identified using an electrospray quadrupole time-of-flight mass spectrometer. Several ozonation pathways were proposed including hydroxylation, demethylation, carbonylation, deamination and methylene group cleavage. Two species of luminescent bacteria Photobacterium phosphoreum and Vibrio qinghaiensis were selected to assess the toxicity of ozonation products. For P. phosphoreum, higher level of toxicity was observed compared to the parent compound, but a negligible toxicity change was observed for V. qinghaiensis, indicating different modes of action for the same water sample. This was further confirmed by quantitative structure-active relationship analysis. This work proves the dominant role of ozone rather than hydroxyl radicals in the reaction and the potential risk after zonation. (C) 2013 Elsevier Ltd. All rights reserved.