Determining anatomical connectivities between cortical and brainstem pain processing regions in humans: A diffusion tensor imaging study in healthy controls
Determining anatomical connectivities between cortical and brainstem pain processing regions in humans: A diffusion tensor imaging study in healthy controls
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DOI：
10.1016/j.pain.2006.02.027
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发表时间：
2006-07-01
期刊：
影响因子：
7.4
通讯作者：
Tracey, Irene
中科院分区：
文献类型：
--
作者：
Hadjipavlou, George;Dunckley, Paul;Tracey, Irene
到目前为止，神经老化方法已经确定了大脑中参与疼痛处理和控制的各种结构。然而，我们对它们的解剖联系的了解相对较弱。弥散张量成像(DTI)是一种基于磁共振成像的方法，可以在体内标测人脑的解剖联系，并被用于研究起源于导水管周围灰质(PAG)和楔状核(NCF)的白质联系。我们对8名健康的右利手男性志愿者进行了DTI检查。群体分析表明，PAG与NCF、前额叶皮质、杏仁核、丘脑、下丘脑和双侧头腹内侧延髓之间的联系可以确定，并对它们的可能性进行量化。已确定的联系证实了存在解剖回路，这些回路通过人类的脑干结构对疼痛处理产生自顶向下的功能特征影响。(C)2006年国际疼痛研究协会。爱思唯尔出版，版权所有。
Neuroiniaging methods have so far identified various structures in the brain involved in the processing of pain and its control. However, our understanding of their anatomical connectivities is relatively weak. Diffusion tensor imaging (DTI), a magnetic resonance imaging-based method, allows in vivo mapping of the anatomical connections in the human brain and was used to investigate the white matter connections originating from the periaquaductal grey (PAG) and nucleus cuneiformis (NCF). We performed DTI on 8 healthy right-handed male volunteers. Group analysis showed that tract paths could be defined and their likelihood quantified for connections between the PAG and separately for the NCF, to the prefrontal cortex, amygdala, thalamus, hypothalamus and rostroventral medial medulla bilaterally. The connections identified confirm the existence of an anatomical circuitry for the functionally characterised top-down influences on pain processing via brainstem structures in humans. (c) 2006 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.