Response of psychotic and nonpsychotic depressed patients to tricyclic antidepressants.
Response of psychotic and nonpsychotic depressed patients to tricyclic antidepressants.
复制标题
精神病性和非精神病性抑郁症患者对三环类抗抑郁药的反应。
DOI：
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发表时间：
1987
影响因子：
5.3
通讯作者：
D. Hedeker
中科院分区：
文献类型：
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作者：
C. Chan;P. Janicak;J. Davis;E. Altman;S. Andriukaitis;D. Hedeker
三环类抗抑郁药（TCAs）的反应进行了研究，在75 121例抑郁症患者分为精神病或非精神病亚型的研究诊断标准。通过临床总体评价量表评估缓解。在75例接受TCA治疗的患者中，40例（68%）非精神病亚型有反应，而精神病亚型只有4例（25%）有反应。调整慢性，性别，年龄，丧失能力，激越，迟滞，内源性，和单极双极的区别作为协变量的影响，它被发现，这些变量未能改变精神病性和非精神病性抑郁症组的差异反应率。对1054例患者的文献回顾显示，67%的非精神病性抑郁症患者对TCA有反应，而精神病性抑郁症患者只有35%。
The response to tricyclic antidepressants (TCAs) is studied in 75 of 121 depressed patients classified as psychotic or nonpsychotic subtypes by Research Diagnostic Criteria. Response was assessed by a clinical global evaluation scale. Of the 75 patients treated with TCAs, 40 (68%) of the nonpsychotic subtype responded in contrast to only 4 (25%) of the psychotic subtype. Adjusting for the effects of chronicity, sex, age, incapacity, agitation, retardation, endogenicity, and the unipolar-bipolar distinction as covariates, it was found that these variables failed to alter the differential response rate of the psychotic and nonpsychotic depressed groups. A literature review of 1054 patients revealed that 67% of the nonpsychotic depressed patients responded to TCAs compared with only 35% of the psychotic depressed patients.