PERIPHERAL NERVOUS-SYSTEM (PNS) EXPRESSION OF MESSENGER-RNAS ENCODING MYELIN PROTEINS AND FC-GAMMA-RIII DURING EXPERIMENTAL ALLERGIC NEURITIS
PERIPHERAL NERVOUS-SYSTEM (PNS) EXPRESSION OF MESSENGER-RNAS ENCODING MYELIN PROTEINS AND FC-GAMMA-RIII DURING EXPERIMENTAL ALLERGIC NEURITIS
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DOI：
10.1016/0165-5728(92)90194-p
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发表时间：
1992-11-01
影响因子：
3.3
通讯作者：
PLEASURE, D
中科院分区：
文献类型：
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作者：
CONTI, G;VEDELER, C;PLEASURE, D
在刘易斯大鼠中注射与牛髓磷脂P2蛋白53-78位氨基酸同源的肽“SP 26”，在完全弗氏佐剂中诱导实验性变态反应性神经炎（EAN）。大鼠在第14天开始出现EAN体征，在第18天达到最大值，并在第30天消退。马尾神经和坐骨神经的RNA含量在EAN高度时增加2倍以上。髓鞘Po和PI mRNA的表达在EAN期间没有下降，在恢复期间也没有上升。Fc γ R mRNA，编码Fc γ RIII，免疫球蛋白结合蛋白介导激活的自然杀伤细胞和巨噬细胞的免疫复合物，是短暂的，但显着诱导分散的神经内细胞，推测巨噬细胞，马尾和坐骨神经期间的增加虚弱。
Experimental allergic neuritis (EAN) was induced in Lewis rats by injection of 'SP26', a peptide homologous to amino acids 53-78 of bovine myelin P2 protein, in complete Freund's adjuvant. The rats developed signs of EAN which began on day 14, were maximal on day 18, and had subsided by day 30. RNA content of cauda equina and sciatic nerves increased more than 2-fold at the height of EAN. Expression of myelin Po and PI mRNAs did not fall during EAN, nor rise during recovery. FcgammaR mRNA, which encodes FcgammaRIII, an immunoglobulin-binding protein mediating activation of natural killer cells and macrophages by immune complexes, was transiently, but markedly induced in scattered endoneural cells, presumably macrophages, in cauda equina and sciatic nerves during the period of increasing weakness.