Chemical Constituents of Euphorbia glomerulans
Chemical Constituents of Euphorbia glomerulans
复制标题
DOI：
10.1007/s10600-021-03350-w
复制
发表时间：
2021-03
影响因子：
0.8
通讯作者：
A. Hasan;C. F. Lu;D. Nijat;H. Aisa
中科院分区：
文献类型：
--
作者：
A. Hasan;C. F. Lu;D. Nijat;H. Aisa
大戟属是大戟科中最大的植物，在世界范围内约有2000种，以其类异戊二烯成分bbb的化学多样性而闻名。大戟属植物在中国共有80种。其中一些已被用作治疗腹痛、腹胀、皮肤病和麻痹症的传统药物。大戟是二萜的丰富来源，具有许多不同的核心框架，如麻风烷、乙烯烷、tiglianes、ingenanes、myrsinols等。此外，还得到倍半萜类、苯乙酮类、脑苷类、甘油类、黄酮类和类固醇。从大大麻中分离出的萜烯具有许多不同的活性，包括抗氧化、抗肿瘤、逆转耐多药、抗菌、血管活性、免疫调节和抗炎作用[10]。大戟（Prokh.）Prokh。主要分布于中国西北部和中亚地区。然而，肾小球芽孢杆菌的植物化学研究尚未见报道。因此，我们研究了七种化合物的纯化和鉴定方法：脱氢马钱子叶醇(1)[5]，榄油内酯(2)[6]，槲皮素3- o -α- l -鼠李糖苷(3)[7],6,7 -二羟基香豆素(4)[8]，4-羟基苯甲酸(5)[9]，4-羟基苯乙酮(6)[10]和enniatin B(7)[11]。其中化合物1、2、3、6为首次从该属植物中分离得到，化合物7为首次从大戟属植物中分离得到。
The genus Euphorbia is the largest in the Euphorbiaceae family with about 2000 species worldwide and is well known for the chemical diversity of their isoprenoid constituents [1]. The plants of the genus Euphorbia consist of 80 species in China. Some of them have been used as traditional medicine to cure abdominal pain, abdominal distention, skin disease, and paralysis [2]. Euphorbia is a rich source of diterpenoids with many different core frameworks such as jatrophanes, lathyranes, tiglianes, ingenanes, myrsinols, etc. In addition, sesquiterpenoids, phloracetophenones, cerebrosides, glycerols, flavonoids, and steroids were also obtained [3].Terpenes isolated from different Euphorbia species are known for many different activities, including antioxidant, antitumor, MDR reversing, antimicrobial, vasoactive, immunomodulatory, and anti-inflammatory effects [4]. Euphorbia glomerulans (Prokh.) Prokh. is mainly distributed in northwestern China and Central Asia. However, the phytochemical research of E. glomerulans has not been reported previously. Therefore, we elucidate the procedure for the purification and identification of seven compounds from E. glomerulans: dehydrovomifoliol (1)[5], loliolide (2)[6], quercitrin 3-O-α-L-rhamnoside (3)[7], 6, 7-dihydroxycoumarin (4)[8], 4-hydroxybenzoic acid (5)[9], 4-hydroxyacetophenone (6)[10], and enniatin B (7)[11]. Among these compounds, 1, 2, 3, and 6 were isolated from this species for the first time, and compound 7 was isolated from the genus Euphorbia for the first time.