SEROEPIDEMIOLOGY OF KLEBSIELLA BACTEREMIC ISOLATES AND IMPLICATIONS FOR VACCINE DEVELOPMENT
SEROEPIDEMIOLOGY OF KLEBSIELLA BACTEREMIC ISOLATES AND IMPLICATIONS FOR VACCINE DEVELOPMENT
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DOI：
10.1128/jcm.23.4.687-690.1986
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发表时间：
1986-04-01
影响因子：
9.4
通讯作者：
GERMANIER, R
中科院分区：
文献类型：
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作者：
CRYZ, SJ;MORTIMER, PM;GERMANIER, R
对703株临床分离的克雷伯菌进行了荚膜血清型频率的测定。超过90%的分离株是可分型的，77个已知血清型中有69个被鉴定。血清型2、21和55分别占所有分离株的8.9%、7.8%和4.8%，观察到的频率显著高于其他荚膜血清型（P < 0.05）。大约43%的血清型出现的频率低于0.5%。比较北美和欧洲分离株的血清流行病学发现了差异。目前的研究结果表明，基于荚膜多糖的克雷伯氏菌疫苗是可行的，应该是多价的，引发针对25种血清型的抗体，这些血清型占所有菌血症分离株的约70%。
The frequencies of capsular serotypes among 703 Klebsiella strains isolated from the blood of hospitalized patients were determined. More than 90% of the isolates were typeable, with 69 of the 77 known serotypes being identified. Serotypes 2, 21, and 55, representing 8.9, 7.8, and 4.8% of all the isolates, respectively, were observed at a frequency significantly higher (P < 0.05) than that for other capsular serotypes. Approximately 43% of the serotypes appeared at a frequency of less than 0.5%. Differences were found when the seroepidemiology of North American and European isolates was compared. The current findings indicate that a capsular polysaccharide-based vaccine against Klebsiella organisms is feasible and should be multivalent, eliciting antibodies directed against the 25 serotypes which make up approximately 70% of all the bacteremic isolates.