Task-Dependent Modulation of Inputs to Proximal Upper Limb Following Transcranial Direct Current Stimulation of Primary Motor Cortex
Task-Dependent Modulation of Inputs to Proximal Upper Limb Following Transcranial Direct Current Stimulation of Primary Motor Cortex
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DOI：
10.1152/jn.01046.2009
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发表时间：
2010-05-01
影响因子：
2.5
通讯作者：
Byblow, Winston D.
中科院分区：
文献类型：
--
作者：
Bradnam, Lynley V.;Stinear, Cathy M.;Byblow, Winston D.
刘志强，刘志强，刘志强。经颅直流电刺激初级运动皮层后上肢近端输入的任务依赖调节。中国生物医学工程学报，2009,31(2):444 - 444。首次发表于2010年3月10日；doi: 10.1152 / jn.01046.2009。阴极经颅直流电刺激（ctDCS）抑制控制对侧手部肌肉的初级运动皮质（M1）的兴奋性。本研究评估了c-tDCS是否对上肢近端肌的单侧和对侧M1投射有相似的影响。左M1经颅磁刺激（TMS）在左M1 c-tDCS之前和之后，以及c-tDCS后20和40分钟，激发左右冈下肌（INF）的运动诱发电位（MEPs）。受试者分别预激活每个干扰素（左、右）或同时预激活两个干扰素（双侧）时，给予经颅磁刺激。c-tDCS后，同侧左INF和对侧右INF的MEPs在左侧任务中被抑制，而在双侧或右侧任务中没有，表明任务依赖性调节。c-tDCS后左INF同侧沉默期缩短，表明经胼胝体抑制改变。这些发现可能对使用tDCS作为中风后上肢近端治疗的辅助治疗具有启示意义。
Bradnam LV, Stinear CM, Lewis GN, Byblow WD. Task- dependent modulation of inputs to proximal upper limb following transcranial direct current stimulation of primary motor cortex. J Neurophysiol 103: 2382-2389, 2010. First published March 10, 2010; doi: 10.1152/jn.01046.2009. Cathodal transcranial DC stimulation (ctDCS) suppresses excitability of primary motor cortex (M1) controlling contralateral hand muscles. This study assessed whether c-tDCS would have similar effects on ipsi- and contralateral M1 projections to a proximal upper limb muscle. Transcranial magnetic stimulation (TMS) of left M1 was used to elicit motor evoked potentials (MEPs) in the left and right infraspinatus (INF) muscle immediately before and after c-tDCS of left M1, and at 20 and 40 min, post-c-tDCS. TMS was delivered as participants preactivated each INF in isolation (left, right) or both INF together (bilateral). After c-tDCS, ipsilateral MEPs in left INF and contralateral MEPs in right INF were suppressed in the left task but not in the bilateral or right tasks, indicative of task-dependent modulation. Ipsilateral silent period duration in the left INF was reduced after c-tDCS, indicative of altered transcallosal inhibition. These findings may have implications for the use of tDCS as an adjunct to therapy for the proximal upper limb after stroke.