Reemergence of Reston ebolavirus in Cynomolgus Monkeys, the Philippines, 2015.
Reemergence of Reston ebolavirus in Cynomolgus Monkeys, the Philippines, 2015.
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DOI：
10.3201/eid2407.171234
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发表时间：
2018-07
影响因子：
11.8
通讯作者：
Fukushi S
中科院分区：
文献类型：
--
作者：
Demetria C;Smith I;Tan T;Villarico D;Simon EM;Centeno R;Tachedjian M;Taniguchi S;Shimojima M;Miranda NLJ;Miranda ME;Rondina MMR;Capistrano R;Tandoc A 3rd;Marsh G;Eagles D;Cruz R;Fukushi S
2015年8月，菲律宾马尼拉南部的一家非人灵长类动物机构发现6只食蟹猴（Macaca fascicularis）出现异常死亡，特征为全身皮疹、食欲不振或猝死。我们通过血清学和分子检测鉴定了猴子中的莱斯顿埃博拉病毒（RESTV）感染。我们从受感染猴子的组织中分离出病毒，并确定了病毒基因组序列。在2015年疫情中发现的RESTV在遗传上更接近于导致2008年猪群疫情的4种RESTV之一。8只猕猴，包括2只也感染了RESTV，麻疹检测呈阳性。与此同时，麻疹病毒在整个菲律宾传播，表明猕猴的感染可能是一种反向人畜共患病。改进生物安全措施将最大限度地减少公共卫生风险，并限制疾病和病媒的传入。
In August 2015, a nonhuman primate facility south of Manila, the Philippines, noted unusual deaths of 6 cynomolgus monkeys (Macaca fascicularis), characterized by generalized rashes, inappetence, or sudden death. We identified Reston ebolavirus (RESTV) infection in monkeys by using serologic and molecular assays. We isolated viruses in tissues from infected monkeys and determined viral genome sequences. RESTV found in the 2015 outbreak is genetically closer to 1 of the 4 RESTVs that caused the 2008 outbreak among swine. Eight macaques, including 2 also infected with RESTV, tested positive for measles. Concurrently, the measles virus was circulating throughout the Philippines, indicating that the infection of the macaques may be a reverse zoonosis. Improved biosecurity measures will minimize the public health risk, as well as limit the introduction of disease and vectors.