Peripherin diverts ciliary ectosome release to photoreceptor disc morphogenesis.
Peripherin diverts ciliary ectosome release to photoreceptor disc morphogenesis.
复制标题
DOI：
10.1083/jcb.201703020
复制
发表时间：
2017-05-01
期刊：
影响因子：
--
通讯作者：
Goldberg AFX
中科院分区：
文献类型：
--
作者：
Molday RS;Goldberg AFX
Molday和Goldberg讨论了Salinas等人描述光感受器细胞感光外段细胞器形成的工作。光感受器细胞中膜盘的形成需要纤毛质膜外翻，其分子机制尚不清楚。Salinas et al.（2017）。[j]细胞生物学。https://doi.org/10.1083/jcb.201608081)表明外周蛋白（也称为外周蛋白-2或外周蛋白-2/rds）通过抑制纤毛外胞体的释放，将膜交通转移到光感受器盘的形成。
Molday and Goldberg discuss work by Salinas et al. describing formation of the light-sensing outer segment organelle of photoreceptor cells. Formation of membrane discs in photoreceptor cells requires evagination of its ciliary plasma membrane by an unknown molecular mechanism. Salinas et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201608081) show that peripherin (also known as peripherin-2 or peripherin-2/rds) diverts membrane traffic to photoreceptor disc formation by inhibiting ectosome release from the cilium.