Molecular and Genetic Predictors of Breast-to-Brain Metastasis: Review and Case Presentation.
Molecular and Genetic Predictors of Breast-to-Brain Metastasis: Review and Case Presentation.
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DOI：
10.7759/cureus.246
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发表时间：
2015-01
期刊：
影响因子：
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通讯作者：
Hayden Gephart M
中科院分区：
文献类型：
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作者：
Medress Z;Hayden Gephart M
脑转移瘤是最常见的颅内恶性肿瘤，乳腺癌是第二常见的脑转移癌。颅内疾病是乳腺癌的晚期表现，很少有有效的治疗选择，影响15-50%的乳腺癌患者，取决于分子亚型。在这篇综述文章中，我们描述了乳腺癌细胞中促进乳腺向脑转移的遗传、分子和代谢变化。我们相信，对乳腺到脑转移发病机制的理解的进步将导致靶向分子治疗，并提高前瞻性识别颅内疾病风险增加患者的能力。
Brain metastases are the most common intracranial malignancy, and breast cancer is the second most common cancer to metastasize to the brain. Intracranial disease is a late manifestation of breast cancer with few effective treatment options, affecting 15-50% of breast cancer patients, depending upon molecular subtype. In this review article, we describe the genetic, molecular, and metabolic changes in breast cancer cells that facilitate breast to brain metastasis. We believe that advances in the understanding of breast to brain metastasis pathogenesis will lead to targeted molecular therapies and to improvements in the ability to prospectively identify patients at increased risk for developing intracranial disease.