Measuring adherence to antiretroviral therapy in children and adolescents in western Kenya.
Measuring adherence to antiretroviral therapy in children and adolescents in western Kenya.
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DOI：
10.7448/ias.17.1.19227
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发表时间：
2014-01-01
影响因子：
6
通讯作者：
Inui, Thomas S
中科院分区：
文献类型：
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作者：
Vreeman, Rachel C;Nyandiko, Winstone M;Inui, Thomas S
引言：高水平的坚持抗逆转录病毒治疗（ART）是艾滋病毒管理的核心。本研究的目的是比较多项措施的坚持和调查因素与艾滋病毒感染的儿童在肯尼亚西部的依从性。方法：我们前瞻性地评估ART坚持6个月的年龄≤14岁的艾滋病毒感染的儿童参加大型门诊艾滋病毒诊所在肯尼亚。使用护理人员报告、血浆药物浓度和药物事件监测系统（MEMS）报告依从性。使用Kappa统计量比较MEMS的依从性估计值。进行逻辑回归分析，以评估儿童、护理人员和家庭特征与二分依从性（MEMS依从性≥90% vs.
INTRODUCTION: High levels of adherence to antiretroviral therapy (ART) are central to HIV management. The objective of this study was to compare multiple measures of adherence and investigate factors associated with adherence among HIV-infected children in western Kenya.METHODS: We evaluated ART adherence prospectively for six months among HIV-infected children aged ≤14 years attending a large outpatient HIV clinic in Kenya. Adherence was reported using caregiver report, plasma drug concentrations and Medication Event Monitoring Systems (MEMS). Kappa statistics were used to compare adherence estimates with MEMS. Logistic regression analyses were performed to assess the association between child, caregiver and household characteristics with dichotomized adherence (MEMS adherence ≥90% vs.