Semicircular canal plane head impulses detect absent function of individual semicircular canals
Semicircular canal plane head impulses detect absent function of individual semicircular canals
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DOI：
10.1093/brain/121.4.699
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发表时间：
1998-04-01
期刊：
影响因子：
14.5
通讯作者：
Hannigan, IP
中科院分区：
文献类型：
--
作者：
Cremer, PD;Halmagyi, GM;Hannigan, IP
我们研究了人类前庭-眼反射（VOR）对头部“脉冲”的反应：短暂的、不可预测的、被动的、高加速度（Mp到4000度/秒(2)）、低振幅（20-30度）的头部旋转。我们在测试的半规管（SCC）平面上传递头部脉冲。为了测试前后SCCs，头部脉冲在正前方（滚动）和矢状面（俯仰）之间的对角线面上传递。我们用巩膜搜索线圈记录了9名正常受试者、7名单侧前庭神经切除术患者和3名单侧SCC后部闭塞患者的头部和眼睛的三维位置。在术后患者中，我们证明了针对任何单一无功能SCC的头部脉冲严重的永久性VOR增益缺陷（0.2-0.3）。该测试的敏感性取决于初级前庭传入神经的生理特性，其特异性取决于SCC的解剖取向。斜头冲量是人类个体垂直SCC功能的第一个测试，它与水平头冲量一起构成了SCC平面测试的综合电池。这些管平面脉冲可用于评估眩晕或其他前庭疾病患者。
We studied the human vestibule-ocular reflex (VOR) in response To head 'impulses': brief unpredictable, passive, high-acceleration (Mp to 4000 degrees/s(2)), low-amplitude (20-30 degrees) head rotations. We delivered the head impulses approximately in the plane of the semicircular canal (SCC) being tested. To test the anterior and posterior SCCs, the head impulses were delivered in a diagonal plane, midway between the frontal (roll) and sagittal (pitch) planes. We recorded head and eye position in three dimensions with scleral search coils in nine normal subjects, seven patients following unilateral surgical vestibular neurectomy and three patients following unilateral posterior SCC occlusion. In the post-surgical patients we demonstrated a severe, permanent VOR gain deficit (0.2-0.3) for head impulses directed toward any single non-functioning SCC. The sensitivity of the test depends on the physiological properties of primary vestibular afferents, and its specificity depends on the anatomical orientation of the SCC's. The diagonal head impulse is the first test of individual vertical SCC function in humans, and together with the horizontal head impulse, forms a comprehensive battery of SCC-plane tests. These canal-plane impulses could he useful in evaluating patients with vertigo or other vestibular disorders.