Multiple Pathways Analysis of Brain Functional Networks from EEG Signals: An Application to Real Data
Multiple Pathways Analysis of Brain Functional Networks from EEG Signals: An Application to Real Data
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DOI：
10.1007/s10548-010-0152-z
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发表时间：
2011-01-01
期刊：
影响因子：
2.7
通讯作者：
Babiloni, Fabio
中科院分区：
文献类型：
--
作者：
Fallani, Fabrizio De Vico;Rodrigues, Francisco Aparecido;Babiloni, Fabio
在本研究中，我们提出了一个理论图的程序来研究大脑功能网络中的多个通路。通过考虑网络节点对之间由h条链路组成的所有可能路径，我们测量了全局网络冗余度R（h）作为并行路径的数量，全局网络渗透率P（h）作为连接的概率。我们用这个程序来调查的结构和动力学的变化，在一组脊髓损伤（SCI）患者的高分辨率EEG信号的数据集估计的皮层网络在尝试脚的运动。根据与健康人群的统计对比，SCI网络的渗透性指数P（h）在Theta频带（3-6 Hz）中对于范围从2至4的距离h显著增加（P < 0.01）。而冗余度指数R（h）在两个种群间差异不显著。SCI患者脑功能网络最显着的变化主要发生在较低的光谱内容中。这些变化与最近的皮层区域之间的通信传播的改善有关，而不是与不同程度的冗余有关。这一证据加强了假设，需要一个更高的功能之间的相互作用最接近的ROI作为一种机制，以补偿缺乏反馈的外周神经的感觉运动区。
In the present study, we propose a theoretical graph procedure to investigate multiple pathways in brain functional networks. By taking into account all the possible paths consisting of h links between the nodes pairs of the network, we measured the global network redundancy R (h) as the number of parallel paths and the global network permeability P (h) as the probability to get connected. We used this procedure to investigate the structural and dynamical changes in the cortical networks estimated from a dataset of high-resolution EEG signals in a group of spinal cord injured (SCI) patients during the attempt of foot movement. In the light of a statistical contrast with a healthy population, the permeability index P (h) of the SCI networks increased significantly (P < 0.01) in the Theta frequency band (3-6 Hz) for distances h ranging from 2 to 4. On the contrary, no significant differences were found between the two populations for the redundancy index R (h) . The most significant changes in the brain functional network of SCI patients occurred mainly in the lower spectral contents. These changes were related to an improved propagation of communication between the closest cortical areas rather than to a different level of redundancy. This evidence strengthens the hypothesis of the need for a higher functional interaction among the closest ROIs as a mechanism to compensate the lack of feedback from the peripheral nerves to the sensomotor areas.