Life course breast cancer risk factors and adult breast density (United Kingdom)?
Life course breast cancer risk factors and adult breast density (United Kingdom)?
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DOI：
10.1007/s10552-004-2473-2
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发表时间：
2004-11-01
影响因子：
2.3
通讯作者：
Smith, GD
中科院分区：
文献类型：
--
作者：
Jeffreys, M;Warren, R;Smith, GD
目的：要确定是否在儿童期和成年早期的危险因素影响以后的乳房X线摄影breast density.Methods：受试者是628名妇女谁参加了医学检查，在大学的格拉斯哥学生健康服务（1948-1968年），回答了一份问卷（2001年），并在苏格兰（1989-2002年）的筛查乳房X线摄影。使用乳腺密度百分比的六类分类（SCC）对乳房X线照片（中位年龄为59岁）进行分类。使用逻辑回归来确定风险因素与高风险乳房X光检查之间的关联结果：在多变量分析中，高危乳腺X线检查与产次相关，（每名儿童的调整优势比（OR）：0.77（95%置信区间（CI）0.61-0.99）），首次生育年龄，每年OR：1.05（0.99-1.11），在大学吸烟，OR吸烟者vs非吸烟者：0.58（0.36-0.92），在大学时体重指数（BMI），OR每1 kg/m2 0.75（0.69-0.82）。未发现与SCC相关的初潮年龄、出生体重、口服避孕药（OC）使用、身高、腿长或20岁时的锻炼。结论：我们证实了以前的研究结果，即乳腺密度受生殖事件和一些人体测量指标的影响，但我们研究的大多数风险因素在整个生命过程中与成人乳腺密度并不密切相关。
Objective: To determine whether risk factors in childhood and early adulthood affect later mammographic breast density.Methods: Subjects were 628 women who attended a medical examination at the University of Glasgow Student Health Service (1948-1968), responded to a questionnaire (2001) and had a screening mammogram in Scotland (1989-2002). Mammograms (median age of 59 years) were classified using a six category classification (SCC) of breast density percent. Logistic regression was used to determine associations between risk factors and having a high-risk mammogram (greater than or equal to25% dense).Results: In multi-variable analyses, high-risk mammograms were associated with parity (adjusted odds ratio (OR) per child: 0.77 (95% confidence interval (CI) 0.61-0.99)), age at first birth, OR per year: 1.05 (0.99-1.11), smoking at university, OR smokers versus non-smokers: 0.58 (0.36-0.92) and body mass index (BMI) while at university, OR per 1 kg/m(2) 0.75 (0.69-0.82). No associations with SCC were found for age at menarche, birth weight, oral contraceptive (OC) use, height, leg length or exercise at age 20.Conclusions: We confirm previous findings that breast density is affected by reproductive events and some anthropometric measures, however most of the risk factors acting throughout the life course which we examined were not closely related to adult breast density.