Pharmacological and Nonpharmacological Treatment for Apathy in Alzheimer Disease
Pharmacological and Nonpharmacological Treatment for Apathy in Alzheimer Disease
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DOI：
10.1177/0891988716678684
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发表时间：
2017-01
影响因子：
2.6
通讯作者：
C. Theleritis;K. Siarkos;E. Katirtzoglou;A. Politis
中科院分区：
文献类型：
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作者：
C. Theleritis;K. Siarkos;E. Katirtzoglou;A. Politis
目的：冷漠是阿尔茨海默病（AD）最常见的神经精神症状之一。 AD 冷漠的早期诊断和及时治疗似乎非常重要，因为冷漠与疾病结果不佳、日常功能下降和护理人员的痛苦有关。设计：在此背景下，我们从国家医学图书馆、PsychInfo 和 Google Scholar 的数据库中进行了广泛的电子检索，以查找研究药物和非药物治疗 AD 冷漠效果的研究。结果：乙酰胆碱酯酶抑制剂、银杏叶、哌醋甲酯和各种非药物干预措施可成功减少 AD 患者的冷漠情绪。研究方法的异质性以及以冷漠作为主要结局指标的少量研究是评估群体效应的限制因素。结论：AD 冷漠的治疗是一个复杂且尚未充分探索的领域。主要关注 AD 冷漠研究的标准化和系统性工作可能会从针对特定疾病组的个体化治疗中获益，这种治疗源于药物和非药物干预的结合。
Objective: Apathy is one of the most frequent neuropsychiatric symptoms encountered in Alzheimer disease (AD). Early diagnosis and timely treatment of apathy in AD seem to be of great importance, since apathy has been associated with poor disease outcome, reduced daily functioning, and caregiver distress. Design: Within this context, we conducted an extensive electronic search from the databases included in the National Library of Medicine as well as PsychInfo and Google Scholar for studies that have investigated the effect of pharmacological and nonpharmacological treatments of apathy in AD. Results: Acetylcholinesterase inhibitors, gingko biloba, methylphenidate, and a variety of nonpharmacological interventions were found to be successful in reducing apathy in patients with AD. Methodological heterogeneity of the studies and the small amount of studies where apathy was a primary outcome measure are limiting factors to evaluate for group effects. Conclusion: Treatment of apathy in AD is a complicated and an underexplored field. Standardized and systematic efforts primarily focused on the study of apathy in AD may establish a benefit from individualized treatment for specific disease groups that would stem from a combination of both pharmacological and nonpharmacological interventions.