Emerging Trends in the Pathological Research of Human Papillomavirus-positive Oropharyngeal Squamous Cell Carcinoma.
Emerging Trends in the Pathological Research of Human Papillomavirus-positive Oropharyngeal Squamous Cell Carcinoma.
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DOI：
10.14218/jctp.2022.00004
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发表时间：
2022
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口咽鳞状细胞癌（OPSCC）的发病率在过去几十年中以惊人的速度增长，尤其是在男性中。在美国，具有转录活性的人乳头瘤病毒（HPV），特别是HPV 16，已成为OPSCC的最大贡献者，每年影响约16，000人。与HPV阴性OPSCC患者相比，HPV阳性OPSCC患者对放化疗表现出更好的健康反应，长期生存率总体增加。尽管有很好的治疗选择，但许多OPSCC是在晚期发现的，约20%的病例在明确治疗后会复发。因此，正在进行广泛的研究，以确定精确治疗的新靶点并对肿瘤预后进行分层。本综述的目的是捕捉HPV阳性OPSCC的最新研究，强调其作为精准医学和生存预后的潜在新靶点的相关性。
Oropharyngeal squamous cell carcinomas (OPSCCs) have shown an alarming rate of increase in incidence over the past several decades, markedly in men. In the United States, transcriptionally-active human papillomavirus (HPV), particularly HPV 16, has become the highest contributive agent of OPSCCs, affecting approximately 16,000 people a year. Compared to patients with HPV-negative OPSCCs, patients with HPV-positive OPSCCs exhibit better health responses to chemoradiotherapy and an overall increase in long-term survival. Despite promising treatment options, many OPSCCs are discovered at an advanced stage, and ~20% of cases will recur after definitive treatment. Therefore, extensive research is ongoing to identify new targets for precision treatment and to stratify tumor prognosis. The aim of this review is to capture the most updated research on HPV-positive OPSCCs, emphasizing their relevance as potential new targets for precision medicine and survival prognosis.