Effect of Acute Myocardial Infarction on Erythrocytic Glutathione Peroxidase 1 Activity and Plasma Vitamin E Levels
Effect of Acute Myocardial Infarction on Erythrocytic Glutathione Peroxidase 1 Activity and Plasma Vitamin E Levels
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DOI：
10.1016/j.amjcard.2008.09.104
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发表时间：
2009-02-15
影响因子：
2.8
通讯作者：
Chlu, Daniel Tsun-yee
中科院分区：
文献类型：
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作者：
Cheng, Mei-ling;Chen, Chin-ming;Chlu, Daniel Tsun-yee
谷胱甘肽过氧化物酶1（GPX-1）在抗氧化防御中具有重要作用，并已被认为对动脉粥样硬化的发病机制具有保护作用。在本研究中，测定了42例急性心肌梗塞患者和285例台湾健康对照者的红细胞GPX-1活性。我们的数据显示，急性心肌梗死患者的GPX-1平均活性降低（40.7 +/- 9.2 vs 47.3 +/- 16.6 U/g血红蛋白; p
Glutathione peroxidase 1 (GPX-1) has an important role in antioxidant defense and has been suggested to have a protective role against the pathogenesis of atherosclerosis. In the present study, erythrocytic GPX-1 activity from 42 patients with acute myocardial infarction and 285 healthy control subjects of Taiwanese origin were determined. Our data showed that mean GPX-1 activity decreased in patients with acute myocardial infarction (40.7 +/- 9.2 vs 47.3 +/- 16.6 U/g hemoglobin; p