A Review of Auxin Response Factors (ARFs) in Plants.
A Review of Auxin Response Factors (ARFs) in Plants.
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植物生长素反应因子（ARF）的综述
DOI：
10.3389/fpls.2016.00047
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发表时间：
2016
影响因子：
5.6
通讯作者：
Zhang JZ
中科院分区：
文献类型：
--
作者：
Li SB;Xie ZZ;Hu CG;Zhang JZ
从胚胎发生到衰老，生长素几乎是植物生长和发育的各个方面的关键调节因子。以前的研究表明，生长素通过一系列功能不同的DNA结合生长素反应因子(ARF)来控制基因表达，从而调节这些过程。ARF可能是通过选择靶基因作为转录因子而赋予生长素反应特异性的成分。它们与生长素调节基因启动子中的生长素反应DNA元件(AuxRE)结合，并根据蛋白质中间的特定结构域激活或抑制这些基因的转录。通过功能缺失突变分析，遗传学研究表明不同的ARF参与了不同的发育过程。最近的研究进展为植物ARF基因的表达调控、ARF在生长发育过程中的作用、ARF的蛋白质-蛋白质相互作用以及受ARF调控的靶基因提供了信息。特别是，ARF蛋白的蛋白质相互作用和结构研究为生长素调节转录的分子基础提供了新的见解。这些结果为预测ARF基因对其他植物生物学的贡献提供了基础。
Auxin is a key regulator of virtually every aspect of plant growth and development from embryogenesis to senescence. Previous studies have indicated that auxin regulates these processes by controlling gene expression via a family of functionally distinct DNA-binding auxin response factors (ARFs). ARFs are likely components that confer specificity to auxin response through selection of target genes as transcription factors. They bind to auxin response DNA elements (AuxRE) in the promoters of auxin-regulated genes and either activate or repress transcription of these genes depending on a specific domain in the middle of the protein. Genetic studies have implicated various ARFs in distinct developmental processes through loss-of-function mutant analysis. Recent advances have provided information on the regulation of ARF gene expression, the role of ARFs in growth and developmental processes, protein–protein interactions of ARFs and target genes regulated by ARFs in plants. In particular, protein interaction and structural studies of ARF proteins have yielded novel insights into the molecular basis of auxin-regulated transcription. These results provide the foundation for predicting the contributions of ARF genes to the biology of other plants.