Cortical grey matter alterations in idiopathic restless legs syndrome: An optimized voxel-based morphometry study
Cortical grey matter alterations in idiopathic restless legs syndrome: An optimized voxel-based morphometry study
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DOI：
10.1002/mds.21608
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发表时间：
2007-09-15
影响因子：
8.6
通讯作者：
Kassubek, Jan
中科院分区：
文献类型：
--
作者：
Unrath, Alexander;Juengling, Freimut D.;Kassubek, Jan
不宁腿综合症（RLS）被认为是中枢体感处理受损。尽管不宁腿综合症的功能神经影像学证据表明，大脑各区域存在广泛的功能变化，但迄今为止，尚未有报道称皮质水平的结构变化与不宁腿综合症有关。在这里，通过使用优化的基于体素的形态测量法对 63 名特发性不宁腿综合征患者进行了高分辨率三维磁共振成像 (MRI) 分析，以研究皮层区域的体积是否可能根据不宁腿综合征的现象在群体水平上发生改变。 RLS 患者与对照组的比较显示，双半球初级体感皮层的灰质体积显着减少，校正后的 P < 0.05，并且还延伸到左侧初级运动区。所有簇都与 RLS 症状的严重程度和疾病持续时间相关。这些结果首次为不宁腿综合征患者的新皮质灰质结构改变提供了体内证据。感觉运动皮层的改变可能会增加特发性不宁腿综合征的病理生理学概念。 (C) 2007 年运动障碍协会。
An impairment of central somatosensory processing is assumed in restless legs syndrome (RLS). Although functional neuroimaging in RLS gave evidence to the presence of widespread functional changes in various brain areas, structural changes at the cortical level were not reported to be RLS-associated to date. Here, an analysis of high-resolution three-dimensional magnetic resonance imaging (MRI) was performed in 63 patients with idiopathic RLS by use of optimized voxel-based morphometry, in order to investigate if cortical areas might be altered in volume at group level according to the phenomenology of RLS. The comparison of the RLS patients versus controls yielded significant regional decreases of gray matter volume at corrected P < 0.05 in the bihemispheric primary somatosensory cortex, which additionally extended into left-sided primary motor areas. All clusters correlated both with the severity of RLS symptoms and with disease duration. These results, for the first time, give in vivo evidence to structural neocortical gray matter alterations in RLS patients. The alterations in the sensorimotor cortices might add to the pathophysiological concepts of idiopathic RLS. (C) 2007 Movement Disorder Society.