The stimulatory effect of cholecystokinin implanted in the medial preoptic area on luteinizing hormone secretion in the ovariectomized estrogen-primed rat.
The stimulatory effect of cholecystokinin implanted in the medial preoptic area on luteinizing hormone secretion in the ovariectomized estrogen-primed rat.
复制标题
植入内侧视前区的胆囊收缩素对切除卵巢的雌激素引发的大鼠黄体生成素分泌的刺激作用。
DOI：
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发表时间：
1983
期刊：
影响因子：
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通讯作者：
M. Kawakami
中科院分区：
文献类型：
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作者：
F. Kimura;R. Hashimoto;M. Kawakami
在雌性去卵巢大鼠模型上，观察了经长期埋置的导管行内侧视前区(MPO)植入CCK-8对促黄体生成素(LH)释放的影响。于术后12.00 h将CCK-8内管植入MPO，并于术后11、12、16.00、18.00、20.00 h采血，用放射免疫法测定血清中黄体生成素的浓度。在MPO中植入空管的动物组，每个采样时间的平均血清LH值没有明显的波动。在MPO内植入CCK-8的动物，LH值随时间波动显著，16.00h达高峰，提示CCK-8能刺激LHRH的释放，作用于MPO。
The effect of implantation of cholecystokinin(CCK)-8 into the medial preoptic area (MPO) through the chronically implanted guide cannula on the release of LH was examined in the ovariectomized estradiol-primed rat. An inner cannula with CCK-8 at the tip, as well as an empty inner cannula as the control, was implanted into the MPO at 12.00 h. Blood samples were obtained at 11.00, 12.00, 16.00, 18.00 and 20.00 h, and serum concentration of LH was measured by RIA. There was no significant fluctuation over time in the mean serum LH values for each sampling time in the group of animals implanted with empty cannulae in the MPO. In the group of animals implanted with CCK-8 into the MPO, the fluctuation of the mean LH values over time was significant, with a marked and significant elevation of LH values peaking at 16.00 h. It was strongly suggested that CCK-8 was capable of stimulating LH-RH release, acting at the MPO.