Integrating systems biology sources illuminates drug action.
Integrating systems biology sources illuminates drug action.
复制标题
DOI：
10.1038/clpt.2014.51
复制
发表时间：
2014-06
影响因子：
6.7
通讯作者：
中科院分区：
文献类型：
--
作者：
There are significant gaps in our understanding of the pathways by which drugs act. This incomplete knowledge limits our ability to use mechanistic molecular information rationally to repurpose drugs, understand their side effects, and predict their interactions with other drugs. Here we present DrugRouter: a novel method for generating drug-specific pathways of action by linking target genes, disease genes and pharmacogenes using gene interaction networks. We construct pathways for over a hundred drugs, and show that the genes included in our pathways co-occur with the query drug in the literature, significantly overlap or are adjacent to known drug-response pathways, and are adjacent to genes that are hits in genome wide association studies assessing drug response. Finally, these computed pathways suggest novel drug repositioning opportunities (e.g., statins for follicular thyroid cancer), gene-side effect associations, and gene-drug interactions. Thus, DrugRouter generates hypotheses about drug actions using systems biology data.
登录
查看更多内容
影响因子：
3.7
作者：
Jung K;LePendu P;Chen WS;Iyer SV;Readhead B;Dudley JT;Shah NH
通讯作者：
Shah NH
影响因子：
5.8
作者：
Lachmann, Alexander;Xu, Huilei;Ma'ayan, Avi
通讯作者：
Ma'ayan, Avi
影响因子：
12.8
作者：
Coyle, TE;Bair, AK;Wright, J
通讯作者：
Wright, J
影响因子：
9.9
作者：
Kuhn M;Campillos M;Letunic I;Jensen LJ;Bork P
通讯作者：
Bork P
影响因子：
14.9
作者：
Chatr-aryamontri, Andrew;Ceol, Arnaud;Palazzi, Luisa Montecchi;Nardelli, Giuliano;Schneider, Maria Victoria;Castagnoli, Luisa;Cesareni, Gianni
通讯作者：
Cesareni, Gianni