PREVENTION OF APOPTOSIS BY A BACULOVIRUS GENE DURING INFECTION OF INSECT CELLS
PREVENTION OF APOPTOSIS BY A BACULOVIRUS GENE DURING INFECTION OF INSECT CELLS
复制标题
DOI：
10.1126/science.1962198
复制
发表时间：
1991-11-29
期刊：
影响因子：
56.9
通讯作者：
MILLER, LK
中科院分区：
文献类型：
--
作者：
CLEM, RJ;FECHHEIMER, M;MILLER, LK
程序性细胞死亡是一种主动的自我毁灭过程，在多细胞动物的发育和维持中都很重要。控制程序性细胞死亡激活或抑制的分子机制在很大程度上是未知的。细胞凋亡是一种在形态学和生物化学上有明确定义的程序性细胞死亡类型，常见于脊椎动物，在昆虫细胞中杆状病毒复制期间被发现启动。一种特定的病毒基因产物p35被确定为负责阻断细胞凋亡反应。该基因功能的确定将有助于进一步明确参与程序性细胞死亡调控的分子途径，并可能确定细胞凋亡在无脊椎动物病毒防御系统中的作用。
Programmed cell death is an active process of self destruction that is important in both the development and maintenance of multicellular animals. The molecular mechanisms controlling activation or suppression of programmed cell death are largely unknown. Apoptosis, a morphologically and biochemically defined type of programmed cell death commonly seen in vertebrates, was found to be initiated during baculovirus replication in insect cells. A specific viral gene product, p35, was identified as being responsible for blocking the apoptotic response. Identification of the function of this gene will allow further definition of the molecular pathways involved in the regulation of programmed cell death and may identify the role of apoptosis in invertebrate viral defense systems.