Activation of peripheral delta-opioid receptors leads to anti-hyperalgesic responses in the masseter muscle of male and female rats.
Activation of peripheral delta-opioid receptors leads to anti-hyperalgesic responses in the masseter muscle of male and female rats.
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DOI：
10.1016/j.neuroscience.2011.05.062
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发表时间：
2011-09-08
期刊：
影响因子：
3.3
通讯作者：
Ro, J. Y.
中科院分区：
文献类型：
--
作者：
Saloman, J. L.;Niu, K. Y.;Ro, J. Y.
在这个项目中，我们检查了雄性和雌性大鼠在急性口面部肌肉疼痛情况下外周 δ-阿片受体 (DOR) 介导的抗痛觉过敏反应。我们还研究了 ATP 敏感 K+ 通道 (KATP)（OR 信号传导的下游靶标）是否有助于 DOR 介导的抗痛觉过敏反应。用 DOR 激动剂 DPDPE 对咬肌进行局部预处理，可剂量依赖性地减弱雄性和雌性大鼠中辣椒素诱导的机械超敏反应。然而，局部 DPDPE 的效力存在性别差异，雌性大鼠需要高 10 倍的 DPDPE 剂量才能产生雄性大鼠的抗痛觉过敏水平。 DPDPE 效应的性别差异可能不能完全用 DOR 表达水平来解释，因为三叉神经节 (TG) 中 DOR mRNA 水平没有显着的性别差异。最后，用 KATP 拮抗剂格列本脲预处理咬肌，显着阻断雄性大鼠中 DPDPE 的作用，表明外周 DOR 效应是由 KATP 介导的。这些研究揭示了口面部肌肉疼痛条件下外周局部 DOR 介导的抗痛觉过敏方面性别差异的新信息。
In this project, we examined peripheral δ-opioid receptor (DOR)-mediated anti-hyperalgesic responses in the context of an acute orofacial muscle pain condition in both male and female rats. We also investigated whether the ATP-sensitive K+ channel (KATP), a downstream target of OR signaling, contributes to DOR-mediated anti-hyperalgesic responses. Local pretreatment of the masseter with a DOR agonist, DPDPE, dose-dependently attenuated capsaicin-induced mechanical hypersensitivity in both male and female rats. However, there were sex differences in the potency of local DPDPE in that a 10 fold higher dose of DPDPE was required in female rats to produce the level of anti-hyperalgesia achieved in male rats. The sex differences in the DPDPE effect may not be fully explained by DOR expression level since there was no significant sex difference in DOR mRNA levels in trigeminal ganglia (TG). Finally, pretreatment of the masseter with the KATP antagonist, glibenclamide significantly blocked the effects of DPDPE in male rats suggesting that the peripheral DOR effect is mediated by the KATP. These studies revealed novel information about sex differences with regards to peripherally localized DOR-mediated anti-hyperalgesia under an orofacial muscle pain condition.
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影响因子：
4.7
作者：
Granados-Soto, V;Argüelles, CF;Ortiz, MI
通讯作者：
Ortiz, MI
影响因子：
7.4
作者：
Guan, Yun;Johanek, Lisa M.;Raja, Srinivasa N.
通讯作者：
Raja, Srinivasa N.
DOI：
10.1152/ajpregu.00824.2005
发表时间：
2006-08-01
影响因子：
2.8
作者：
Ji, Yaping;Murphy, Anne Z.;Traub, Richard J.
通讯作者：
Traub, Richard J.
影响因子：
7.4
作者：
Eisenach, JC;Carpenter, R;Curry, R
通讯作者：
Curry, R
影响因子：
5
作者：
Leanez, Sergi;Hervera, Arnau;Pol, Olga
通讯作者：
Pol, Olga