Role of H3K4 monomethylation in gene regulation.
Role of H3K4 monomethylation in gene regulation.
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DOI：
10.1016/j.gde.2024.102153
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发表时间：
2024-01
影响因子：
4
通讯作者：
Zhaoning Wang;Bing Ren
中科院分区：
文献类型：
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作者：
Zhaoning Wang;Bing Ren
H3 K4单甲基化（H3 K4 me 1）是一种保守的组蛋白标记，参与基因调控的各个阶段。本文综述了支持和反对H3 K4 me 1在基因调控中直接作用的数据。我们提出了一个新的概念框架来调和这些实验观察。组蛋白H3在赖氨酸-4残基上的甲基化（H3 K4 me 1）在整个真核结构域中被发现，其作为从酵母到哺乳动物细胞的活性转录的保守表观遗传标记的最初发现有助于组蛋白密码假说。然而，最近的研究提出了一个问题，即不同形式的H3 K4 me是否在基因调控中发挥直接作用，或者只是转录过程的副产物。在这里，我们回顾了经常相互矛盾的实验证据，集中在组蛋白H3上的赖氨酸4的单甲基化，这与后生动物中增强子的转录状态有关。我们认为，这种表观遗传标记的行为在上下文依赖的方式，直接促进基因组的转录输出和细胞身份的建立。
HighlightsH3K4 monomethylation (H3K4me1) is a conserved histone mark.H3K4me1 is implicated in various regulatory stages of gene regulation.Data supporting and opposing a direct role of H3K4me1 in gene regulation are reviewed.We propose a new conceptual framework to reconcile these experimental observations.Methylation of histone H3 on the lysine-4 residue (H3K4me) is found throughout the eukaryotic domain, and its initial discovery as a conserved epigenetic mark of active transcription from yeast to mammalian cells has contributed to the histone code hypothesis. However, recent studies have raised questions on whether the different forms of H3K4me play a direct role in gene regulation or are simply by-products of the transcription process. Here, we review the often-conflicting experimental evidence, focusing on the monomethylation of lysine 4 on histone H3 that has been linked to the transcriptional state of enhancers in metazoans. We suggest that this epigenetic mark acts in a context-dependent manner to directly facilitate the transcriptional output of the genome and the establishment of cellular identity.