Dermatophyte virulence factors: identifying and analyzing genes that may contribute to chronic or acute skin infections.
Dermatophyte virulence factors: identifying and analyzing genes that may contribute to chronic or acute skin infections.
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DOI：
10.1155/2012/358305
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发表时间：
2012
影响因子：
3.4
通讯作者：
White TC
中科院分区：
文献类型：
--
作者：
Achterman RR;White TC
皮肤真菌是皮肤真菌病的常见原因，与许多其他真菌病原体不同，它能够在免疫能力强的人身上引起疾病。它们感染角化组织，如皮肤、头发和指甲，导致癣感染，包括癣。人们对这些生物体建立和维持感染能力的分子机制知之甚少。最近基因组序列信息的可获得性和改进的遗传操作使研究人员能够开始识别和研究皮肤真菌毒力因子的作用。本文将总结我们目前对皮肤真菌毒力因子的认识，并讨论未来鉴定和检测毒力因子的方向。
Dermatophytes are prevalent causes of cutaneous mycoses and, unlike many other fungal pathogens, are able to cause disease in immunocompetent individuals. They infect keratinized tissue such as skin, hair, and nails, resulting in tinea infections, including ringworm. Little is known about the molecular mechanisms that underlie the ability of these organisms to establish and maintain infection. The recent availability of genome sequence information and improved genetic manipulation have enabled researchers to begin to identify and study the role of virulence factors of dermatophytes. This paper will summarize our current understanding of dermatophyte virulence factors and discuss future directions for identifying and testing virulence factors.