Effects of Intrauterine Growth Restriction During Late Pregnancy on the Development of the Ovine Fetal Thymus and the T-Lymphocyte Subpopulation
Effects of Intrauterine Growth Restriction During Late Pregnancy on the Development of the Ovine Fetal Thymus and the T-Lymphocyte Subpopulation
复制标题
妊娠晚期宫内生长限制对绵羊胎儿胸腺和 T 淋巴细胞亚群发育的影响
DOI：
10.1111/aji.12371
复制
发表时间：
2015-07-01
影响因子：
3.6
通讯作者：
Gao, Feng
中科院分区：
文献类型：
--
作者：
Liu, Yingchun;He, Shan;Gao, Feng
ProblemThe retarded development of fetal thymus in intrauterine growth restriction (IUGR) from maternal undernutrition during late pregnancy destroys the tridimensional structure and modifies the development of fetal T lymphocytes. The mechanisms, however, remain unclear. The objective of this study was to investigate the effect of IUGR during late pregnancy on the development of the ovine fetal thymus and the T-lymphocyte subpopulation.Method of studyEighteen time-mated ewes with singleton fetuses were allocated to three groups at day 90 of pregnancy: restricted group 1 (RG1, 0.18 MJ ME/BW0.75/day, n=6), restricted group 2 (RG2, 0.33 MJ ME/BW0.75/day, n=6) and a control group (CG, ad libitum, 0.67 MJ ME/BW0.75/day, n=6). Fetuses were recovered at slaughter on day 140.ResultsFetuses in RG1 exhibited decreased (P
