Proposal of Gleason-like grading system of canine prostate carcinoma in veterinary pathology practice
Proposal of Gleason-like grading system of canine prostate carcinoma in veterinary pathology practice
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DOI：
10.1016/j.rvsc.2015.09.004
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发表时间：
2015-12-01
影响因子：
2.4
通讯作者：
Grieco, Valeria
中科院分区：
文献类型：
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作者：
Palmieri, Chiara;Grieco, Valeria
Gleason分级-男性前列腺癌预后最有用的预测因子-在2005年国际泌尿病理学会的共识会议上更新。鉴于Gleason样生长模式在犬前列腺癌中已被认可，本研究将改良的Gleason分级应用于45例犬前列腺癌，其中28例为单一原发性生长模式，11例为继发性生长模式，6例为三级生长模式。筛状、实性和小腺泡/导管分别是最常见的原发、继发和三级形态学类型，Gleason评分最高（GS 10）的病例占46.7%。14例转移病例中有9例被归类为GS 10。Gleason 5型33例。这项研究表明，修改后的格里森分级，根据特定的组织学生长模式存在于犬前列腺癌，可以接受作为一个分级系统的组织病理学在实践中设置，以完成临床评估的最佳管理的病人。(C)2015爱思唯尔有限公司版权所有。
Gleason grading - the most useful predictor of prognosis for prostate cancer in men - was updated at a 2005 consensus conference by the International Society of Urological Pathology. Since Gleason-like growth patterns have been recognised in dogs, this study aimed to apply the modified Gleason grading to 45 canine prostate carcinomas.A single primary growth pattern was observed in 28 cases, a secondary pattern in 11 cases and a tertiary pattern in 6 cases. Cribriform, solid and small acinar/ductal were the most common primary, secondary and tertiary morphological patterns, respectively.The highest Gleason score (GS10) was obtained in 46.7% of cases. Nine of 14 metastasizing cases were classified as GS10. Gleason pattern 5 was present in 33 of cases. This study suggests that the modified Gleason grading, based on specific histological growth patterns existing in canine prostate carcinomas, may be accepted as a grading system for histopathology in the practice settings in order to complete the clinical assessment for the best management of the patient. (C) 2015 Elsevier Ltd. All rights reserved.