Induction of cellular and molecular immunomodulatory pathways by vitamin A and flavonoids.
Induction of cellular and molecular immunomodulatory pathways by vitamin A and flavonoids.
复制标题
DOI：
10.1517/14712598.2015.1066331
复制
发表时间：
2015
影响因子：
4.6
通讯作者：
Vajdy M
中科院分区：
文献类型：
--
作者：
Patel S;Vajdy M
对维生素A和选择类黄酮的免疫调节特性的报告的详细研究可能为使用这些天然化合物或具有类似结构的化合物在针对感染性和自身免疫性疾病和癌症的新型药物和疫苗设计中铺平道路。综述了细胞内信号转导途径、细胞分化和功能性免疫调节反应。报道的研究包括体外、体内临床前和临床研究，这些研究阐述了维生素A和选择的类黄酮在诱导先天性和适应性B和T细胞应答（包括TH1、TH2和Treg）中的作用。虽然维生素A和相关化合物的免疫调节作用在许多临床前研究中得到了充分证实，但其在人类中的作用已开始获得更广泛的认可。相比之下，类黄酮的作用在临床试验中大多是有争议的，这是由于这些化合物的各种类别的多样性，并且可能是由于化合物的纯度和所选择的剂量。然而，目前的临床前和临床研究需要对这些有前途的免疫调节化合物进行进一步的详细研究。
A detailed study of reports on the immunomodulatory properties of vitamin A and select flavonoids may pave the way for using these natural compounds or compounds with similar structures in novel drug and vaccine designs against infectious and autoimmune diseases and cancers. Intracellular transduction pathways, cellular differentiation and functional immunomodulatory responses have been reviewed. The reported studies encompass in vitro, in vivo preclinical and clinical studies that address the role of Vitamin A and select flavonoids in induction of innate and adaptive B and T cell responses, including TH1, TH2 and Treg. While the immunomodulatory role of vitamin A, and related compounds, is well-established in many preclinical studies, its role in humans has begun to gain wider acceptance. In contrast, the role of flavonoids is mostly controversial in clinical trials, due to the diversity of the various classes of these compounds, and possibly due to the purity and the selected doses of the compounds. However, current preclinical and clinical studies warrant further detailed studies of these promising immuno-modulatory compounds.