Optimization of the Nitroxide-Mediated Radical Polymerization Conditions for Styrene and tert-Butyl Acrylate in an Automated Parallel Synthesizer
Optimization of the Nitroxide-Mediated Radical Polymerization Conditions for Styrene and tert-Butyl Acrylate in an Automated Parallel Synthesizer
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自动并行合成器中硝基氧介导的苯乙烯和丙烯酸叔丁酯自由基聚合条件的优化
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发表时间：
2006
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通讯作者：
U. Schubert
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作者：
C. R. Becer;Renzo M. Paulus;R. Hoogenboom;U. Schubert
自动化平行合成仪可在相似条件下对不同聚合参数进行快速、可比的筛选。此外，这些机器人系统消除了操作错误，操作错误可能会影响动力学实验的结果，而不是重要参数的影响。对苯乙烯和丙烯酸叔丁酯均聚反应的聚合温度和N，N-叔丁基-N-（1，0 -二乙基膦酰基-2，2，0 -二甲基丙基）氮氧自由基浓度进行了优化，在保持合理聚合速率的前提下，改善了对聚合反应的控制。随后，根据从筛选结果获得的知识合成聚苯乙烯和聚（丙烯酸叔丁酯）大分子引发剂。这些大分子引发剂用于制备苯乙烯-丙烯酸叔丁酯嵌段共聚物。Wiley Periodicals，Inc.聚合物科学杂志A部分：聚合物化学44：6202-6213，2006年
Automated parallel synthesizers provide fast and comparable screening of different polymerization parameters under similar conditions. In addition, these robotic systems eliminate handling errors, which may affect the results of a kinetic experiment more than the effect of an important parameter. The polymerization tem- perature and N,N-tert-butyl-N-(1 0 -diethylphosphono-2,2 0 -dimethylpropyl)nitroxide con- centration were optimized for the homopolymerization of both styrene and tert-butyl acrylate to improve the control over the polymerization while reasonable polymeriza- tion rates were retained. Subsequently, polystyrene and poly(tert-butyl acrylate) macro- initiators were synthesized according to the knowledge obtained from the screening results. These macroinitiators were used for the preparation of block copolymers con- sisting of styrene and tert-butyl acrylate. V C 2006 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 44: 6202-6213, 2006