Independent mutations in the Rdl locus confer dieldrin resistance to Anopheles gambiae and An. arabiensis
Independent mutations in the Rdl locus confer dieldrin resistance to Anopheles gambiae and An. arabiensis
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DOI：
10.1111/j.1365-2583.2005.00544.x
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发表时间：
2005-04-01
影响因子：
2.6
通讯作者：
Zheng, L
中科院分区：
文献类型：
--
作者：
Du, W;Awolola, TS;Zheng, L
用丝氨酸或甘氨酸取代编码γ-氨基丁酸（GABA）受体亚基的Rdl基因座中的保守丙氨酸残基赋予多种昆虫物种对狄氏剂的抗性。在这里，我们表明，丙氨酸甘氨酸取代的Rdl基因座的疟疾载体，冈比亚按蚊，遗传上与耐狄氏剂。在抗狄氏剂的An菌株中独立地开发了丙氨酸到丝氨酸的取代。阿拉伯的。等位基因特异性聚合酶链反应（PCR）检测能够区分狄氏剂抗性和敏感蚊子。
Substitutions of a conserved alanine residue in the Rdl locus coding for a gamma-aminobutyric acid (GABA) receptor subunit with serine or glycine confer resistance to dieldrin in various insect species. Here, we show that alanine to glycine substitution in the Rdl locus of the malaria vector, Anopheles gambiae, is genetically linked to resistance to dieldrin. An alanine to serine substitution developed independently in a dieldrin resistant strain of An. arabiensis. An allele-specific polymerase chain reaction (PCR) assay was able to differentiate dieldrin resistant and susceptible mosquitoes.