Questioning patients about their adolescent history can identify markers associated with deep infiltrating endometriosis
Questioning patients about their adolescent history can identify markers associated with deep infiltrating endometriosis
复制标题
DOI：
10.1016/j.fertnstert.2010.10.027
复制
发表时间：
2011-03-01
影响因子：
6.7
通讯作者：
de Ziegler, Dominique
中科院分区：
文献类型：
--
作者：
Chapron, Charles;Lafay-Pillet, Marie-Christine;de Ziegler, Dominique
目的：为了调查是否临床病史，特别是青春期，包含标志物的深度浸润性子宫内膜异位症（DIE）。设计：横断面研究。设置：大学三级转诊中心。患者：229例手术治疗子宫内膜异位症。子宫内膜异位病变经组织学证实为非DIE（浅表腹膜子宫内膜异位症和/或卵巢腺瘤）（n = 131）或DIE（n = 98）。干预：手术切除子宫内膜异位症病变并对每个标本进行病理分析。主要结果测量：流行病学资料，盆腔疼痛评分，子宫内膜异位症家族史，月经期间旷课，结果：DIE患者有明显更多的子宫内膜异位症家族史（优势比[OR] 3.2; 95%可信区间[CI]：1.2-8.8），月经期间缺课的比例更高（优势比[OR] 1.7; 95% CI：1-3）。OC丸治疗重度原发性痛经在DIE患者中更常见（OR 4.5; 95%CI：1.9-10.4）。DIE患者使用OC药丸治疗重度原发性痛经的持续时间较长（8.4 ± 4.7年vs. 5.1 ± 3.8年）。在DIE患者中，18岁以前因重度原发性痛经使用OC丸的发生率更高（OR 4.2; 95%CI：1.8-10.0）。结论：了解青春期病史可以识别子宫内膜异位症手术患者中与DIE相关的标志物。（Fertil Steril（R）2011; 95：877-81. (C)美国生殖医学会（American Society for Reproductive Medicine）
Objective: To investigate whether the clinical history, particularly of the adolescence period, contains markers of deeply infiltrating endometriosis (DIE).Design: Cross-sectional study.Setting: Universitary tertiary referral center.Patient(s): Two hundred twenty-nine patients operated on for endometriosis. Endometriotic lesions were histologically confirmed as non-DIE (superficial peritoneal endometriosis and/or ovarian endometriomas) (n = 131) or DIE (n = 98).Intervention(s): Surgical excision of endometriotic lesions with pathological analysis of each specimens.Main Outcome Measure(s): Epidemiological data, pelvic pain scores, family history of endometriosis, absenteeism from school during menstruation, oral contraceptive (OC) pill use.Result(s): Patients with DIE had significantly more positive family history of endometriosis (odds ratio [OR] 3.2; 95% confidence interval [CI]: 1.2-8.8) and more absenteeism from school during menstruation (OR 1.7; 95% CI: 1-3). The OC pill use for treating severe primary dysmenorrhea was more frequent in patients with DIE (OR 4.5; 95% CI: 1.9-10.4). Duration of OC pill use for severe primary dysmenorrhea was longer in patients with DIE (8.4 +/- 4.7 years vs. 5.1 +/- 3.8 years). There was a higher incidence of OC pill use for severe primary dysmenorrhea before 18 years of age in patients with DIE (OR 4.2; 95% CI: 1.8-10.0).Conclusion(s): The knowledge of adolescent period history can identify markers that are associated with DIE in patients undergoing surgery for endometriosis. (Fertil Steril (R) 2011; 95: 877-81. (C) 2011 by American Society for Reproductive Medicine.)