Hijacking of eukaryotic functions by intracellular bacterial pathogens.
Hijacking of eukaryotic functions by intracellular bacterial pathogens.
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细胞内细菌病原体劫持真核功能。
DOI：
10.2436/im.v7i3.9469
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发表时间：
2004
期刊：
影响因子：
--
通讯作者：
F. García
中科院分区：
文献类型：
--
作者：
A. Alonso;F. García
细胞内细菌病原体已进化为一组具有武器的微生物，可以劫持真核细胞的许多生物过程。本综述讨论了这些病原体如何扰乱不同的宿主细胞功能，例如细胞骨架动力学和细胞器囊泡运输。细胞骨架的改变在细菌进入过程（入侵）的背景下进行讨论，该过程通过激活位于膜上的宿主受体（“拉链”机制）或通过将细菌蛋白注射到宿主细胞胞浆中（“触发”机制）来发生。此外，还比较了细胞内生活方式的两种主要类型，即胞质生活方式和液泡内生活方式（吞噬体生活方式），这是吞噬体-溶酶体成熟途径改变的结果。提供了说明已知的模仿或劫持宿主目标的机制的具体示例。最后，描述了胞内细菌吞噬体蛋白质组学和基因组表达的最新进展。这些新技术为了解这些特殊的细菌病原体如何操纵哺乳动物宿主细胞提供了宝贵的线索。
Intracellular bacterial pathogens have evolved as a group of microorganisms endowed with weapons to hijack many biological processes of eukaryotic cells. This review discusses how these pathogens perturb diverse host cell functions, such as cytoskeleton dynamics and organelle vesicular trafficking. Alteration of the cytoskeleton is discussed in the context of the bacterial entry process (invasion), which occurs either by activation of membrane-located host receptors ("zipper" mechanism) or by injection of bacterial proteins into the host cell cytosol ("trigger" mechanism). In addition, the two major types of intracellular lifestyles, cytosolic versus intravacuolar (phagosomal), which are the consequence of alterations in the phagosome-lysosome maturation route, are compared. Specific examples illustrating known mechanisms of mimicry or hijacking of the host target are provided. Finally, recent advances in phagosome proteomics and genome expression in intracellular bacteria are described. These new technologies are yielding valuable clues as to how these specialized bacterial pathogens manipulate the mammalian host cell.