Clinical pattern of human immunodeficiency virus-associated sensory neuropathy among adults in Kano, Northwestern Nigeria
Clinical pattern of human immunodeficiency virus-associated sensory neuropathy among adults in Kano, Northwestern Nigeria
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尼日利亚西北部卡诺成人人类免疫缺陷病毒相关感觉神经病的临床模式
DOI：
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
L. Owolabi
中科院分区：
文献类型：
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作者：
M. Rabiu;A. Ibrahim;A. Yakasai;M. Hamza;L. Owolabi
背景资料：周围神经病变对人类免疫缺陷病毒（HIV）阳性个体的药物依从性和生活质量（包括身体和情感功能）有影响。这对她们执行日常任务的能力产生了相当大的削弱性影响，有时可能是长期的。该研究评估了尼日利亚西北部卡诺市HIV相关感觉神经病变（HIV-SN）的发生频率和决定因素，以期提供最佳护理。方法学：采用系统随机抽样方法，对380名HIV阳性的门诊就诊者进行了一项横断面调查，其中进行了简短的周围神经病变筛查（BPNS）良性家族性新生儿癫痫发作工具。使用逻辑回归统计对潜在风险变量进行多变量分析建模，以确定它们是否是HIV-SN的独立预测因子。结果：在380名研究参与者中，263名（69.2%）为女性，平均年龄为37.4 ± 9.9岁。参与者的平均CD 4计数和诊断HIV感染的持续时间分别为484.5 ± 254.9个细胞/mm 3和60.9 ± 43.5个月。使用BPNS筛查（BPNS）工具，29.2%（111/380）的参与者患有HIV-SN。年龄>40岁（OR 5.86，95% CI = 2.48-13.88，P < 0.001）和联合抗病毒治疗类型（OR 0.36，95% CI = 0.17-0.73，P = 0.005）是HIV-SN的独立影响因素。结论：HIV-SN的发生频率和决定因素提示需要加强对HIV感染者的早期筛查和治疗，以提高他们的整体生活质量。
Background: Peripheral neuropathy has implications for drug adherence and quality of life including the physical and emotional functioning in human immunodeficiency virus (HIV)-positive individuals. The debilitating impact on the ability to carry out their daily tasks is considerable and may sometimes become longstanding. The study assessed the frequency and determinants of HIV-associated sensory neuropathy (HIV-SN) in Kano, Northwestern Nigeria, with a view to provide optimal care. Methodology: A cross-sectional survey where the brief peripheral neuropathy screening (BPNS) benign familial neonatal seizures tool was administered to 380 HIV-positive clinic attendees using systematic random sampling was carried out. Potential risk variables were subjected to multivariate analysis modeling using logistic regression statistics to determine if they are independent predictors of the HIV-SN. Results: Of the 380 study participants, 263 (69.2%) were females, with a mean age of 37.4 ± 9.9 years. The mean CD4 count and duration of the diagnosis of HIV infection of the participants were 484.5 ± 254.9 cells/mm3 and 60.9 ± 43.5 months, respectively. Using the BPNS screening (BPNS) tool, 29.2% (111/380) of the participants had HIV-SN. Independent determinants of HIV-SN in our included age >40 years (odd ratio [OR] 5.86, 95% confidential interval [CI] = 2.48–13.88, P < 0.001) and type of highly active antiretroviral therapy combination used (OR 0.36, 95% CI = 0.17–0.73, P = 0.005). Conclusion: The frequency and determinants of HIV-SN prompt the need to strengthen early screening and treatment of HIV-infected patients by physicians managing them, to improve their overall quality of life.