The amygdala and schizophrenia:: A volumetric magnetic resonance imaging study in first-episode, neuroleptic-naive patients
The amygdala and schizophrenia:: A volumetric magnetic resonance imaging study in first-episode, neuroleptic-naive patients
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DOI：
10.1016/s0006-3223(03)00597-3
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发表时间：
2003-12-01
影响因子：
10.6
通讯作者：
Hietala, J
中科院分区：
文献类型：
--
作者：
Joyal, CC;Laakso, MP;Hietala, J
背景资料：试图评估杏仁核体积使用磁共振成像（MRI）在精神分裂症患者产生了高度分歧的result.Methods：杏仁核的22名健康参与者和18名抗精神病药首次发作的精神分裂症患者，同时控制颅内面积，性别，年龄，和handedish.Results：人与精神分裂症提出了显着降低杏仁核体积双边。杏仁核体积和疾病的持续时间或症状severity.Conclusions之间没有显着的相关性：杏仁核体积异常已经存在于精神分裂症的早期阶段。
Background: The attempts to evaluate amygdaloid volumes using magnetic resonance imaging (MRI) in patients with schizophrenia have yielded highly divergent results.Methods: Volumes of the amygdala were measured in 22 healthy participants and 18 neuroleptic-naive patients with first-episode schizophrenia, while controlling for intracranial area, gender, age, and handedness.Results: Persons with schizophrenia presented significantly lower amygdaloid volumes bilaterally. No significant correlations were found between the amygdaloid volumes and either the duration of the disease or the symptom severity.Conclusions: Amygdaloid volume anomalies are already present in the early phases of schizophrenia.