Health-related quality of life of patients with juvenile idiopathic arthritis coming from 3 different geographic areas.: The PRINTO multinational quality of life cohort study
Health-related quality of life of patients with juvenile idiopathic arthritis coming from 3 different geographic areas.: The PRINTO multinational quality of life cohort study
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DOI：
10.1093/rheumatology/kel218
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发表时间：
2007-02-01
期刊：
影响因子：
5.5
通讯作者：
Ruperto, N.
中科院分区：
文献类型：
--
作者：
Gutierrez-Suarez, R.;Pistorio, A.;Ruperto, N.
目标.比较来自三个地理区域的幼年特发性关节炎（JIA）患者的健康相关生活质量（HRQL），并确定HRQL差的临床决定因素。通过儿童健康问卷（CHQ）评估HRQL。总共有30个国家被列入，分为三个地理区域：西欧16个国家;东欧10个国家;拉丁美洲4个国家。低HRQL的潜在决定因素包括人口统计学数据、医生和父母的总体评估、关节炎症指标、儿童健康评估问卷（CHAQ）和红细胞沉降率测量的残疾。差HRQL定义为CHQ身体总分（PhS）或心理社会总分（PsS）< 2 S。D.与健康儿童的差异。共有3167例年龄小于18岁的JIA患者纳入本研究。最受影响的健康概念（< 2 S。D.区分这三个地理区域的指标（来自健康儿童）包括身体功能、身体疼痛/不适、总体健康、一般健康观念、与前一年相比的健康变化、自尊和家庭凝聚力。不同地理区域的HRQL差的决定因素相似，身体健康主要受残疾程度的影响，而心理社会健康受疼痛强度的影响。我们发现，与健康的同龄人相比，JIA患者的HRQL有显着的损害，特别是在物理领域。残疾和疼痛是身体和心理健康的最重要决定因素，无论其原籍地在何处。
Objectives. To compare health-related quality of life (HRQL) and to identify clinical determinants for poor HRQL of patients with juvenile idiopathic arthritis (JIA) coming from three geographic areas.Methods. The HRQL was assessed through the Child Health Questionnaire (CHQ). A total of 30 countries were included grouped in three geographic areas: 16 countries in Western Europe; 10 in Eastern Europe; and four in Latin America. Potential determinants of poor HRQL included demographic data, physician's and parent's global assessments, measures of joint inflammation, disability as measured by Childhood Health Assessment Questionnaire (CHAQ) and erythrocyte sedimentation rate. Poor HRQL was defined as a CHQ physical summary score (PhS) or psychosocial summary score (PsS) < 2 S. D. from that of healthy children.Results. A total of 3167 patients with JIA, younger than 18 yrs, were included in this study. The most affected health concepts (< 2 S. D. from healthy children) that differentiate the three geographic areas include physical functioning, bodily pain/discomfort, global health, general health perception, change in health with respect to the previous year, self-esteem and family cohesion. Determinants for poor HRQL were similar across geographic areas with physical well-being mostly affected by the level of disability while the psychosocial well-being by the intensity of pain.Conclusion. We found that patients with JIA have a significant impairment of their HRQL compared with healthy peers, particularly in the physical domain. Disability and pain are the most important determinants of physical and psychosocial well-being irrespective of the geographic area of origin.